Cargando…

Role of ubenimex as an anticancer drug and its synergistic effect with Akt inhibitor in human A375 and A2058 cells

BACKGROUND: Malignant melanoma (MM) is a malignant tumor produced by changes in melanocytes in the skin or other organs. In the classification of skin tumor mortality, skin melanoma ranks the highest. Ubenimex, an Aminopeptidase N (APN) inhibitor, is now widely used for cancer as an adjunct therapy,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiaoqing, Liu, Yang, Wu, Rongde, Guo, Feng, Zhang, Lijuan, Cui, Mingyu, Wu, Xiangyu, Zhang, Yongfei, Liu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826084/ https://www.ncbi.nlm.nih.gov/pubmed/29503569 http://dx.doi.org/10.2147/OTT.S157480

Ejemplares similares

Ubenimex, an APN inhibitor, could serve as an anti-tumor drug in RT112 and 5637 cells by operating in an Akt-associated manner
por: Wang, Xiaoqing, et al.
Publicado: (2018)

A CD13 inhibitor, ubenimex, synergistically enhances the effects of anticancer drugs in hepatocellular carcinoma
por: YAMASHITA, MASAFUMI, et al.
Publicado: (2016)

Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells
por: Han, Liping, et al.
Publicado: (2017)

Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism
por: Liu, Shuai, et al.
Publicado: (2016)

The Synergistic Activity of Bortezomib and TIC10 against A2058 Melanoma Cells
por: Takács, Angéla, et al.
Publicado: (2021)

Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines
por: Han, Liping, et al.
Publicado: (2017)

COLLABORATION AGREEMENT KE2058/TE
por: THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLAER PHYSICS OF THE ACADEMY OF SCIENCES, POLAND, et al.
Publicado: (2012)

Inhibition of Tumor Cell Invasion by Ubenimex (Bestatin) in vitro
por: Saiki, Ikuo, et al.
Publicado: (1989)

Synergistic Effect of Eugenol and Probiotic Lactobacillus Plantarum Zs2058 against Salmonella Infection in C57bl/6 Mice
por: Song, Fanfen, et al.
Publicado: (2020)

Discovery of a Novel Ubenimex Derivative as a First-in-Class Dual CD13/Proteasome Inhibitor for the Treatment of Cancer
por: Zhang, Jian, et al.
Publicado: (2023)

Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro
por: Chang, Chin-Kuo, et al.
Publicado: (2022)

Association between different levels of lipid metabolism-related enzymes and fatty acid synthase in Wilms’ tumor
por: Wang, Xiaoqing, et al.
Publicado: (2019)

Corrigendum: Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro
por: Chang, Chin-Kuo, et al.
Publicado: (2022)

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer
por: Tsukamoto, Hirohisa, et al.
Publicado: (2008)

2058 miRNA manipulation to improve CFTR correction in cystic fibrosis
por: Harris, William Thomas, et al.
Publicado: (2018)

Anti-Proliferative and Anti-Migratory Activities of Hispidulin on Human Melanoma A2058 Cells
por: Chang, Chi-Jen, et al.
Publicado: (2021)

2058. Comparison of Drug Resistance Rates of Mycobacterium tuberculosis by the Conventional Drug Susceptibility Test and Sequencing Method
por: Kim, Han-Sung
Publicado: (2018)

miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT
por: Wang, Bin, et al.
Publicado: (2016)

Ubenimex Combined with Pemetrexed Upregulates SOCS1 to Inhibit Lung Adenocarcinoma Progression via the JAK2-STAT3 Signaling Pathway
por: Chen, Quan, et al.
Publicado: (2022)

Laparoscopic extraction of a urethral self-inflicted needle from pelvis in a boy: a case report
por: Wang, Xiaoqing, et al.
Publicado: (2023)

2058: Are atrial fibrillation patient-reported outcomes associated with person and environment characteristics?
por: Gleason, Kelly, et al.
Publicado: (2018)

2058. Patient Satisfaction Not Impacted by Antibiotic Prescribing for Viral Upper Respiratory Infections
por: Ray, Michael J, et al.
Publicado: (2019)

Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
por: Liu, Junsheng, et al.
Publicado: (2019)

Ubenimex Activates the E‐Cadherin‐mediated Adhesion of a Breast Cancer Cell Line YMB‐S
por: Fujioka, Seiji, et al.
Publicado: (1995)

Multimechanism Synergistic Photodetectors with Ultrabroad Spectrum Response from 375 nm to 10 µm
por: Wang, Xudong, et al.
Publicado: (2019)

PReS-FINAL-2058: Lipid peroxides, lipophuscin, sulfhydryl groups and TOS in children with JIA
por: Mazur Zielinska, H, et al.
Publicado: (2013)

Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
por: Wang, Yanjun, et al.
Publicado: (2019)

Ubenimex suppresses Pim-3 kinase expression by targeting CD13 to reverse MDR in HCC cells
por: Guo, Qie, et al.
Publicado: (2017)

Ubenimex suppresses glycolysis mediated by CD13/Hedgehog signaling to enhance the effect of cisplatin in liver cancer
por: Shi, Yunyan, et al.
Publicado: (2023)

Inhibitory effect of Ubenimex combined with fluorouracil on multiple drug resistance and P‐glycoprotein expression level in non‐small lung cancer
por: Wan, Jun, et al.
Publicado: (2020)

Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes
por: Jalava, Jari, et al.
Publicado: (2004)

Food allergy and anaphylaxis – 2058. Elucidation of a 31 Kda cross-reactive kidney bean
por: Nagendra, Komarla, et al.
Publicado: (2013)

Cytotoxic Effect of Clerosterol Isolated from Codium fragile on A2058 Human Melanoma Cells
por: Kim, Areum Daseul, et al.
Publicado: (2013)

Ubenimex Suppresses the Ability of Migration and Invasion in Gastric Cancer Cells by Alleviating the Activity of the CD13/NAB1/MAPK Pathway
por: Liu, Xuehui, et al.
Publicado: (2021)

Combination of immunogenic oncolytic adenovirus ONCOS-102 with anti-PD-1 pembrolizumab exhibits synergistic antitumor effect in humanized A2058 melanoma huNOG mouse model
por: Kuryk, Lukasz, et al.
Publicado: (2018)

Cytotoxic effect of Ginkgo biloba kernel extract on HCT116 and A2058 cancer cell lines
por: Feodorova, Yana, et al.
Publicado: (2020)

PB2058: SCREENING FOR ANTINEUTROPHIL ANTIBODIES IN PATIENTS WITH SEVERE CHRONIC NEUTROPENIA AT ALEXANDRIA UNIVERSITY CHILDREN’S HOSPITAL
por: Werby, Ahmed, et al.
Publicado: (2023)

Akt inhibitors: mechanism of action and implications for anticancer therapeutics
por: Bhutani, Jaikrit, et al.
Publicado: (2013)

Ubenimex induces autophagy inhibition and EMT suppression to overcome cisplatin resistance in GC cells by perturbing the CD13/EMP3/PI3K/AKT/NF-κB axis
por: Guo, Qie, et al.
Publicado: (2019)

MicroRNA-375: potential cancer suppressor and therapeutic drug
por: Wei, Jiahui, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_92dnlct1q40hpg3e6fj204obqk