Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis

AmBisome (LAmB), a liposomal formulation of amphotericin B (AmB), is a second-line treatment for the parasitic skin disease cutaneous leishmaniasis (CL). Little is known about its tissue distribution and pharmacodynamics to inform clinical use in CL. Here, we compared the skin pharmacokinetics of LA...

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Detalles Bibliográficos
Autores principales: Wijnant, Gert-Jan, Van Bocxlaer, Katrien, Yardley, Vanessa, Harris, Andy, Murdan, Sudaxshina, Croft, Simon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826151/
https://www.ncbi.nlm.nih.gov/pubmed/29263075
http://dx.doi.org/10.1128/AAC.02009-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826151/
https://www.ncbi.nlm.nih.gov/pubmed/29263075
http://dx.doi.org/10.1128/AAC.02009-17

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