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Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses
PURPOSE: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826305/ https://www.ncbi.nlm.nih.gov/pubmed/29503526 http://dx.doi.org/10.2147/OPTH.S152201 |
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author | Carson, Daniel Lee, Sangyeol Alexander, Elsinore Wei, Xin Lee, Shinwook |
author_facet | Carson, Daniel Lee, Sangyeol Alexander, Elsinore Wei, Xin Lee, Shinwook |
author_sort | Carson, Daniel |
collection | PubMed |
description | PURPOSE: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and a new high dynamic range (HDR) system. MATERIALS AND METHODS: One monofocal, 1 extended depth of focus, and 4 multifocal IOLs were evaluated. An off-the-shelf optical bench was used to simulate a distant (>50 m) car headlight and record images. A custom HDR system was constructed using an imaging photometer to simulate headlight images and to measure quantitative halo luminance data. A metric was developed to characterize halo luminance properties. Clinical relevance was investigated by correlating halo measurements to visual outcomes questionnaire data. RESULTS: The Optikos system produced halo images useful for visual comparisons; however, measurements were relative and not quantitative. The HDR halo system provided objective and quantitative measurements used to create a metric from the area under the curve (AUC) of the logarithmic normalized halo profile. This proposed metric differentiated between IOL models, and linear regression analysis found strong correlations between AUC and subjective clinical ratings of halos. CONCLUSION: The HDR system produced quantitative, preclinical metrics that correlated to patients’ subjective perception of halos. |
format | Online Article Text |
id | pubmed-5826305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58263052018-03-02 Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses Carson, Daniel Lee, Sangyeol Alexander, Elsinore Wei, Xin Lee, Shinwook Clin Ophthalmol Original Research PURPOSE: Multifocal intraocular lenses (IOLs) can be associated with unwanted visual phenomena, including halos. Predicting potential for halos is desirable when designing new multifocal IOLs. Halo images from 6 IOL models were compared using the Optikos modulation transfer function bench system and a new high dynamic range (HDR) system. MATERIALS AND METHODS: One monofocal, 1 extended depth of focus, and 4 multifocal IOLs were evaluated. An off-the-shelf optical bench was used to simulate a distant (>50 m) car headlight and record images. A custom HDR system was constructed using an imaging photometer to simulate headlight images and to measure quantitative halo luminance data. A metric was developed to characterize halo luminance properties. Clinical relevance was investigated by correlating halo measurements to visual outcomes questionnaire data. RESULTS: The Optikos system produced halo images useful for visual comparisons; however, measurements were relative and not quantitative. The HDR halo system provided objective and quantitative measurements used to create a metric from the area under the curve (AUC) of the logarithmic normalized halo profile. This proposed metric differentiated between IOL models, and linear regression analysis found strong correlations between AUC and subjective clinical ratings of halos. CONCLUSION: The HDR system produced quantitative, preclinical metrics that correlated to patients’ subjective perception of halos. Dove Medical Press 2018-02-21 /pmc/articles/PMC5826305/ /pubmed/29503526 http://dx.doi.org/10.2147/OPTH.S152201 Text en © 2018 Carson et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Carson, Daniel Lee, Sangyeol Alexander, Elsinore Wei, Xin Lee, Shinwook Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title | Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title_full | Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title_fullStr | Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title_full_unstemmed | Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title_short | Comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
title_sort | comparison of two laboratory-based systems for evaluation of halos in intraocular lenses |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826305/ https://www.ncbi.nlm.nih.gov/pubmed/29503526 http://dx.doi.org/10.2147/OPTH.S152201 |
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