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The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis

As the embryonic ectoderm is induced to form the neural plate, cells inside this epithelium acquire restricted identities that will dictate their behavior and progressive differentiation. The first behavior adopted by most neural plate cells is called neurulation, a morphogenetic movement shaping th...

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Detalles Bibliográficos
Autores principales: Giger, Florence A., Houart, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826324/
https://www.ncbi.nlm.nih.gov/pubmed/29515359
http://dx.doi.org/10.3389/fnins.2018.00087
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author Giger, Florence A.
Houart, Corinne
author_facet Giger, Florence A.
Houart, Corinne
author_sort Giger, Florence A.
collection PubMed
description As the embryonic ectoderm is induced to form the neural plate, cells inside this epithelium acquire restricted identities that will dictate their behavior and progressive differentiation. The first behavior adopted by most neural plate cells is called neurulation, a morphogenetic movement shaping the neuroepithelium into a tube. One cell population is not adopting this movement: the eye field. Giving eye identity to a defined population inside the neural plate is therefore a key neural fate decision. While all other neural population undergo neurulation similarly, converging toward the midline, the eye field moves outwards, away from the rest of the forming neural tube, to form vesicles. Thus, while delay in acquisition of most other fates would not have significant morphogenetic consequences, defect in the establishment of the eye field would dramatically impact the formation of the eye. Yet, very little is understood of the molecular and cellular mechanisms driving them. Here, we summarize what is known across vertebrate species and propose a model highlighting what is required to form the essential vesicles that initiate the vertebrate eyes.
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spelling pubmed-58263242018-03-07 The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis Giger, Florence A. Houart, Corinne Front Neurosci Neuroscience As the embryonic ectoderm is induced to form the neural plate, cells inside this epithelium acquire restricted identities that will dictate their behavior and progressive differentiation. The first behavior adopted by most neural plate cells is called neurulation, a morphogenetic movement shaping the neuroepithelium into a tube. One cell population is not adopting this movement: the eye field. Giving eye identity to a defined population inside the neural plate is therefore a key neural fate decision. While all other neural population undergo neurulation similarly, converging toward the midline, the eye field moves outwards, away from the rest of the forming neural tube, to form vesicles. Thus, while delay in acquisition of most other fates would not have significant morphogenetic consequences, defect in the establishment of the eye field would dramatically impact the formation of the eye. Yet, very little is understood of the molecular and cellular mechanisms driving them. Here, we summarize what is known across vertebrate species and propose a model highlighting what is required to form the essential vesicles that initiate the vertebrate eyes. Frontiers Media S.A. 2018-02-21 /pmc/articles/PMC5826324/ /pubmed/29515359 http://dx.doi.org/10.3389/fnins.2018.00087 Text en Copyright © 2018 Giger and Houart. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Giger, Florence A.
Houart, Corinne
The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title_full The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title_fullStr The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title_full_unstemmed The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title_short The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis
title_sort birth of the eye vesicle: when fate decision equals morphogenesis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826324/
https://www.ncbi.nlm.nih.gov/pubmed/29515359
http://dx.doi.org/10.3389/fnins.2018.00087
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