DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy

The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoam...

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Detalles Bibliográficos
Autores principales: Tsai, Hsiang-I, Jiang, Lijuan, Zeng, Xiaowei, Chen, Hongbo, Li, Zihuang, Cheng, Wei, Zhang, Jinxie, Pan, Jie, Wan, Dong, Gao, Li, Xie, Zhenhua, Huang, Laiqiang, Mei, Lin, Liu, Gan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826327/
https://www.ncbi.nlm.nih.gov/pubmed/29515445
http://dx.doi.org/10.3389/fphar.2018.00119
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author Tsai, Hsiang-I
Jiang, Lijuan
Zeng, Xiaowei
Chen, Hongbo
Li, Zihuang
Cheng, Wei
Zhang, Jinxie
Pan, Jie
Wan, Dong
Gao, Li
Xie, Zhenhua
Huang, Laiqiang
Mei, Lin
Liu, Gan
author_facet Tsai, Hsiang-I
Jiang, Lijuan
Zeng, Xiaowei
Chen, Hongbo
Li, Zihuang
Cheng, Wei
Zhang, Jinxie
Pan, Jie
Wan, Dong
Gao, Li
Xie, Zhenhua
Huang, Laiqiang
Mei, Lin
Liu, Gan
author_sort Tsai, Hsiang-I
collection PubMed
description The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoamine)-polyglutamic acid-b-D-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PGlu-b-TPGS) and DACHPt. NP-TPGS-Pt showed robust stability and pH-responsive DACHPt release profile in vitro similar to the PEG-containing nanoparticle (NP-PEG-Pt). Meanwhile, in contrast with NP-PEG-Pt, NP-TPGS-Pt exhibited efficient nanoparticle-based cellular uptake by the Pt-resistant A549/DDP human lung cancer cells and caused much more cytotoxicity than free Oxaliplatin and NP-PEG-Pt. Finally, this NP-TPGS-Pt was proved to perform outstanding inhibition of Pt-resistant tumor growth, much superior than free Oxaliplatin and NP-PEG-Pt. Thus, this NP-TPGS-Pt provides a novel powerful nanomedicine platform for combatting multidrug resistant cancer.
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spelling pubmed-58263272018-03-07 DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy Tsai, Hsiang-I Jiang, Lijuan Zeng, Xiaowei Chen, Hongbo Li, Zihuang Cheng, Wei Zhang, Jinxie Pan, Jie Wan, Dong Gao, Li Xie, Zhenhua Huang, Laiqiang Mei, Lin Liu, Gan Front Pharmacol Pharmacology The clinical applications of platinum-based antitumor agents are still largely limited by severe side effects as well as multidrug resistance (MDR). To solve these problems, we developed an 1,2-diaminocyclohexane-platinum(II) (DACHPt)-loaded nanoparticle (NP-TPGS-Pt) by self-assembly of poly(amidoamine)-polyglutamic acid-b-D-α-tocopheryl polyethylene glycol 1000 succinate (PAM-PGlu-b-TPGS) and DACHPt. NP-TPGS-Pt showed robust stability and pH-responsive DACHPt release profile in vitro similar to the PEG-containing nanoparticle (NP-PEG-Pt). Meanwhile, in contrast with NP-PEG-Pt, NP-TPGS-Pt exhibited efficient nanoparticle-based cellular uptake by the Pt-resistant A549/DDP human lung cancer cells and caused much more cytotoxicity than free Oxaliplatin and NP-PEG-Pt. Finally, this NP-TPGS-Pt was proved to perform outstanding inhibition of Pt-resistant tumor growth, much superior than free Oxaliplatin and NP-PEG-Pt. Thus, this NP-TPGS-Pt provides a novel powerful nanomedicine platform for combatting multidrug resistant cancer. Frontiers Media S.A. 2018-02-21 /pmc/articles/PMC5826327/ /pubmed/29515445 http://dx.doi.org/10.3389/fphar.2018.00119 Text en Copyright © 2018 Tsai, Jiang, Zeng, Chen, Li, Cheng, Zhang, Pan, Wan, Gao, Xie, Huang, Mei and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tsai, Hsiang-I
Jiang, Lijuan
Zeng, Xiaowei
Chen, Hongbo
Li, Zihuang
Cheng, Wei
Zhang, Jinxie
Pan, Jie
Wan, Dong
Gao, Li
Xie, Zhenhua
Huang, Laiqiang
Mei, Lin
Liu, Gan
DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title_full DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title_fullStr DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title_full_unstemmed DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title_short DACHPt-Loaded Nanoparticles Self-assembled from Biodegradable Dendritic Copolymer Polyglutamic Acid-b-D-α-Tocopheryl Polyethylene Glycol 1000 Succinate for Multidrug Resistant Lung Cancer Therapy
title_sort dachpt-loaded nanoparticles self-assembled from biodegradable dendritic copolymer polyglutamic acid-b-d-α-tocopheryl polyethylene glycol 1000 succinate for multidrug resistant lung cancer therapy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826327/
https://www.ncbi.nlm.nih.gov/pubmed/29515445
http://dx.doi.org/10.3389/fphar.2018.00119
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