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Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D(2) Dopamine Receptor

The dopamine D2 receptor (D2R) is known to elicit effects through activating two major signaling pathways mediated by either G proteins (Gi/o) or β-arrestins. However, the specific role of each pathway in physiological or therapeutic activities is not known with certainty. One approach to the dissec...

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Detalles Bibliográficos
Autores principales:	Chun, Lani S., Vekariya, Rakesh H., Free, R. Benjamin, Li, Yun, Lin, Da-Ting, Su, Ping, Liu, Fang, Namkung, Yoon, Laporte, Stephane A., Moritz, Amy E., Aubé, Jeffrey, Frankowski, Kevin J., Sibley, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826336/ https://www.ncbi.nlm.nih.gov/pubmed/29515433 http://dx.doi.org/10.3389/fnsyn.2018.00002

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