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Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients

Accumulating evidence from neuroimaging studies suggests that primary insomnia (PI) affects interregional neural coordination of multiple interacting functional brain networks. However, a complete understanding of the whole-brain network organization from a system-level perspective in PI is still la...

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Autores principales: Ma, Xiaofen, Jiang, Guihua, Fu, Shishun, Fang, Jin, Wu, Yunfan, Liu, Mengchen, Xu, Guang, Wang, Tianyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826384/
https://www.ncbi.nlm.nih.gov/pubmed/29515469
http://dx.doi.org/10.3389/fpsyt.2018.00046
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author Ma, Xiaofen
Jiang, Guihua
Fu, Shishun
Fang, Jin
Wu, Yunfan
Liu, Mengchen
Xu, Guang
Wang, Tianyue
author_facet Ma, Xiaofen
Jiang, Guihua
Fu, Shishun
Fang, Jin
Wu, Yunfan
Liu, Mengchen
Xu, Guang
Wang, Tianyue
author_sort Ma, Xiaofen
collection PubMed
description Accumulating evidence from neuroimaging studies suggests that primary insomnia (PI) affects interregional neural coordination of multiple interacting functional brain networks. However, a complete understanding of the whole-brain network organization from a system-level perspective in PI is still lacking. To this end, we investigated in topological organization changes in brain functional networks in PI. 36 PI patients and 38 age-, sex-, and education-matched healthy controls were recruited. All participants underwent a series of neuropsychological assessments and resting-state functional magnetic resonance imaging scans. Individual whole-brain functional network were constructed and analyzed using graph theory-based network approaches. There were no significant differences with respect to age, sex, or education between groups (P > 0.05). Graph-based analyses revealed that participants with PI had a significantly higher total number of edges (P = 0.022), global efficiency (P = 0.014), and normalized global efficiency (P = 0.002), and a significantly lower normalized local efficiency (P = 0.042) compared with controls. Locally, several prefrontal and parietal regions, the superior temporal gyrus, and the thalamus exhibited higher nodal efficiency in participants with PI (P < 0.05, false discovery rate corrected). In addition, most of these regions showed increased functional connectivity in PI patients (P < 0.05, corrected). Finally, altered network efficiency was correlated with neuropsychological variables of the Epworth Sleepiness Scale and Insomnia Severity Index in patients with PI. PI is associated with abnormal organization of large-scale functional brain networks, which may account for memory and emotional dysfunction in people with PI. These findings provide novel implications for neural substrates associated with PI.
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spelling pubmed-58263842018-03-07 Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients Ma, Xiaofen Jiang, Guihua Fu, Shishun Fang, Jin Wu, Yunfan Liu, Mengchen Xu, Guang Wang, Tianyue Front Psychiatry Psychiatry Accumulating evidence from neuroimaging studies suggests that primary insomnia (PI) affects interregional neural coordination of multiple interacting functional brain networks. However, a complete understanding of the whole-brain network organization from a system-level perspective in PI is still lacking. To this end, we investigated in topological organization changes in brain functional networks in PI. 36 PI patients and 38 age-, sex-, and education-matched healthy controls were recruited. All participants underwent a series of neuropsychological assessments and resting-state functional magnetic resonance imaging scans. Individual whole-brain functional network were constructed and analyzed using graph theory-based network approaches. There were no significant differences with respect to age, sex, or education between groups (P > 0.05). Graph-based analyses revealed that participants with PI had a significantly higher total number of edges (P = 0.022), global efficiency (P = 0.014), and normalized global efficiency (P = 0.002), and a significantly lower normalized local efficiency (P = 0.042) compared with controls. Locally, several prefrontal and parietal regions, the superior temporal gyrus, and the thalamus exhibited higher nodal efficiency in participants with PI (P < 0.05, false discovery rate corrected). In addition, most of these regions showed increased functional connectivity in PI patients (P < 0.05, corrected). Finally, altered network efficiency was correlated with neuropsychological variables of the Epworth Sleepiness Scale and Insomnia Severity Index in patients with PI. PI is associated with abnormal organization of large-scale functional brain networks, which may account for memory and emotional dysfunction in people with PI. These findings provide novel implications for neural substrates associated with PI. Frontiers Media S.A. 2018-02-21 /pmc/articles/PMC5826384/ /pubmed/29515469 http://dx.doi.org/10.3389/fpsyt.2018.00046 Text en Copyright © 2018 Ma, Jiang, Fu, Fang, Wu, Liu, Xu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ma, Xiaofen
Jiang, Guihua
Fu, Shishun
Fang, Jin
Wu, Yunfan
Liu, Mengchen
Xu, Guang
Wang, Tianyue
Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title_full Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title_fullStr Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title_full_unstemmed Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title_short Enhanced Network Efficiency of Functional Brain Networks in Primary Insomnia Patients
title_sort enhanced network efficiency of functional brain networks in primary insomnia patients
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826384/
https://www.ncbi.nlm.nih.gov/pubmed/29515469
http://dx.doi.org/10.3389/fpsyt.2018.00046
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