The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168

Growth signals, such as extracellular nutrients and growth factors, have significant impacts on genome integrity, while the direct underlying link remains unclear. Here we show that the mechanistic target of rapamycin (mTOR)-ribosomal S6 kinase (S6K) pathway, a central regulator of growth signaling,...

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Detalles Bibliográficos
Autores principales: Xie, Xiaoduo, Hu, Hongli, Tong, Xinyuan, Li, Long, Liu, Xiangyuan, Chen, Min, Yuan, Huairui, Xie, Xia, Li, Qingrun, Zhang, Yuxue, Ouyang, Huafang, Wei, Mengqi, Huang, Jing, Liu, Pengda, Gan, Wenjian, Liu, Yong, Xie, Anyong, Kuai, Xiaoling, Chirn, Gung-Wei, Zhou, Hu, Zeng, Rong, Hu, Ronggui, Qin, Jun, Meng, Fei-Long, Wei, Wenyi, Ji, Hongbin, Gao, Daming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826806/
https://www.ncbi.nlm.nih.gov/pubmed/29403037
http://dx.doi.org/10.1038/s41556-017-0033-8

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