VIRMA mediates preferential m(6)A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

N(6)-methyladenosine (m(6)A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however....

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Detalles Bibliográficos
Autores principales: Yue, Yanan, Liu, Jun, Cui, Xiaolong, Cao, Jie, Luo, Guanzheng, Zhang, Zezhou, Cheng, Tao, Gao, Minsong, Shu, Xiao, Ma, Honghui, Wang, Fengqin, Wang, Xinxia, Shen, Bin, Wang, Yizhen, Feng, Xinhua, He, Chuan, Liu, Jianzhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826926/
https://www.ncbi.nlm.nih.gov/pubmed/29507755
http://dx.doi.org/10.1038/s41421-018-0019-0

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