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Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

Myocardial ischemia–reperfusion injury (IRI) leads to the stabilization of the transcription factors hypoxia-inducible factor 1-alpha (HIF1-alpha) and hypoxia-inducible factor 2-alpha (HIF2-alpha). While previous studies implicate HIF1-alpha in cardioprotection, the role of HIF2-alpha remains elusiv...

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Detalles Bibliográficos
Autores principales:	Koeppen, Michael, Lee, Jae W., Seo, Seong-Wook, Brodsky, Kelley S., Kreth, Simone, Yang, Ivana V., Buttrick, Peter M., Eckle, Tobias, Eltzschig, Holger K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827027/ https://www.ncbi.nlm.nih.gov/pubmed/29483579 http://dx.doi.org/10.1038/s41467-018-03105-2

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