Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses

Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation i...

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Autores principales: Schatz, Valentin, Neubert, Patrick, Rieger, Franz, Jantsch, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827161/
https://www.ncbi.nlm.nih.gov/pubmed/29520262
http://dx.doi.org/10.3389/fimmu.2018.00216
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author Schatz, Valentin
Neubert, Patrick
Rieger, Franz
Jantsch, Jonathan
author_facet Schatz, Valentin
Neubert, Patrick
Rieger, Franz
Jantsch, Jonathan
author_sort Schatz, Valentin
collection PubMed
description Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses.
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spelling pubmed-58271612018-03-08 Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses Schatz, Valentin Neubert, Patrick Rieger, Franz Jantsch, Jonathan Front Immunol Immunology Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms potentially contribute to local tissue oxygenation in leishmanial lesions. Moreover, we review the role of hypoxia and HIF-1 on innate antileishmanial immune responses. Frontiers Media S.A. 2018-02-22 /pmc/articles/PMC5827161/ /pubmed/29520262 http://dx.doi.org/10.3389/fimmu.2018.00216 Text en Copyright © 2018 Schatz, Neubert, Rieger and Jantsch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schatz, Valentin
Neubert, Patrick
Rieger, Franz
Jantsch, Jonathan
Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title_full Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title_fullStr Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title_full_unstemmed Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title_short Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
title_sort hypoxia, hypoxia-inducible factor-1α, and innate antileishmanial immune responses
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827161/
https://www.ncbi.nlm.nih.gov/pubmed/29520262
http://dx.doi.org/10.3389/fimmu.2018.00216
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