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A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan

OBJECTIVE: Chikungunya fever (CHIK) is a re-emerging arboviral disease that is transmitted through the bite of infected Aedes mosquitoes. There is limited information regarding the epidemiology and clinical information of imported CHIK in Japan. The objective of this study was to review the epidemio...

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Autores principales: Kutsuna, Satoshi, Kato, Yasuyuki, Katanami, Yuichi, Yamamoto, Kei, Takeshita, Nozomi, Hayakawa, Kayoko, Kanagawa, Shuzo, Ohmagari, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827309/
https://www.ncbi.nlm.nih.gov/pubmed/29093380
http://dx.doi.org/10.2169/internalmedicine.8196-16
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author Kutsuna, Satoshi
Kato, Yasuyuki
Katanami, Yuichi
Yamamoto, Kei
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Ohmagari, Norio
author_facet Kutsuna, Satoshi
Kato, Yasuyuki
Katanami, Yuichi
Yamamoto, Kei
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Ohmagari, Norio
author_sort Kutsuna, Satoshi
collection PubMed
description OBJECTIVE: Chikungunya fever (CHIK) is a re-emerging arboviral disease that is transmitted through the bite of infected Aedes mosquitoes. There is limited information regarding the epidemiology and clinical information of imported CHIK in Japan. The objective of this study was to review the epidemiology and clinical information of imported CHIK patients treated at the National Center for Global Health and Medicine (NCGM). METHODS: We evaluated all patients (n=16) who were diagnosed with imported CHIK and treated at the NCGM between October 1, 2005 and March 31, 2016. RESULTS: The primary complaint of 7 patients who presented to the NCGM after 31 days from disease onset was persistent arthritis, and the primary complaints of 9 patients who presented within 30 days after disease onset were a fever, headache, arthralgia, and rash. Eleven patients experienced a rash during the first week of illness. The median duration of the arthralgia was 75 days, and the joint pain lasted for >2 months in 8 patients and >6 months in 3 patients. Persistent arthralgia was not significantly associated with an age of >35 years (p=0.13) or patient sex (p=0.69). All 16 patients exhibited positive results for CHIK IgM, although only 4 exhibited positive real-time polymerase chain reaction results. CONCLUSION: Physicians should consider CHIK in patients with a fever who have returned from areas where CHIK is endemic.
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spelling pubmed-58273092018-02-28 A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan Kutsuna, Satoshi Kato, Yasuyuki Katanami, Yuichi Yamamoto, Kei Takeshita, Nozomi Hayakawa, Kayoko Kanagawa, Shuzo Ohmagari, Norio Intern Med Original Article OBJECTIVE: Chikungunya fever (CHIK) is a re-emerging arboviral disease that is transmitted through the bite of infected Aedes mosquitoes. There is limited information regarding the epidemiology and clinical information of imported CHIK in Japan. The objective of this study was to review the epidemiology and clinical information of imported CHIK patients treated at the National Center for Global Health and Medicine (NCGM). METHODS: We evaluated all patients (n=16) who were diagnosed with imported CHIK and treated at the NCGM between October 1, 2005 and March 31, 2016. RESULTS: The primary complaint of 7 patients who presented to the NCGM after 31 days from disease onset was persistent arthritis, and the primary complaints of 9 patients who presented within 30 days after disease onset were a fever, headache, arthralgia, and rash. Eleven patients experienced a rash during the first week of illness. The median duration of the arthralgia was 75 days, and the joint pain lasted for >2 months in 8 patients and >6 months in 3 patients. Persistent arthralgia was not significantly associated with an age of >35 years (p=0.13) or patient sex (p=0.69). All 16 patients exhibited positive results for CHIK IgM, although only 4 exhibited positive real-time polymerase chain reaction results. CONCLUSION: Physicians should consider CHIK in patients with a fever who have returned from areas where CHIK is endemic. The Japanese Society of Internal Medicine 2017-11-01 2018-02-01 /pmc/articles/PMC5827309/ /pubmed/29093380 http://dx.doi.org/10.2169/internalmedicine.8196-16 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Kutsuna, Satoshi
Kato, Yasuyuki
Katanami, Yuichi
Yamamoto, Kei
Takeshita, Nozomi
Hayakawa, Kayoko
Kanagawa, Shuzo
Ohmagari, Norio
A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title_full A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title_fullStr A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title_full_unstemmed A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title_short A Retrospective Single-center Analysis of 16 Cases of Imported Chikungunya Fever in Japan
title_sort retrospective single-center analysis of 16 cases of imported chikungunya fever in japan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827309/
https://www.ncbi.nlm.nih.gov/pubmed/29093380
http://dx.doi.org/10.2169/internalmedicine.8196-16
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