Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease

A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid d...

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Autores principales: Iwamoto, Junichi, Murakami, Masashi, Konishi, Naoki, Monma, Tadakuni, Ueda, Hajime, Yara, Shoichiro, Hirayama, Takeshi, Ikegami, Tadashi, Honda, Akira, Matsuzaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827312/
https://www.ncbi.nlm.nih.gov/pubmed/29093413
http://dx.doi.org/10.2169/internalmedicine.9322-17
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author Iwamoto, Junichi
Murakami, Masashi
Konishi, Naoki
Monma, Tadakuni
Ueda, Hajime
Yara, Shoichiro
Hirayama, Takeshi
Ikegami, Tadashi
Honda, Akira
Matsuzaki, Yasushi
author_facet Iwamoto, Junichi
Murakami, Masashi
Konishi, Naoki
Monma, Tadakuni
Ueda, Hajime
Yara, Shoichiro
Hirayama, Takeshi
Ikegami, Tadashi
Honda, Akira
Matsuzaki, Yasushi
author_sort Iwamoto, Junichi
collection PubMed
description A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and weaning the patient off PSL remained impossible. In contrast, additional treatment with clarithromycin completely healed the refractory active ulcer and left only a scar. Furthermore, the ulcer has since maintained the scar stage despite successfully weaning the patient from PSL.
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spelling pubmed-58273122018-02-28 Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease Iwamoto, Junichi Murakami, Masashi Konishi, Naoki Monma, Tadakuni Ueda, Hajime Yara, Shoichiro Hirayama, Takeshi Ikegami, Tadashi Honda, Akira Matsuzaki, Yasushi Intern Med Case Report A 66-year-old Japanese male with a history of Behçet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and weaning the patient off PSL remained impossible. In contrast, additional treatment with clarithromycin completely healed the refractory active ulcer and left only a scar. Furthermore, the ulcer has since maintained the scar stage despite successfully weaning the patient from PSL. The Japanese Society of Internal Medicine 2017-11-01 2018-02-01 /pmc/articles/PMC5827312/ /pubmed/29093413 http://dx.doi.org/10.2169/internalmedicine.9322-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iwamoto, Junichi
Murakami, Masashi
Konishi, Naoki
Monma, Tadakuni
Ueda, Hajime
Yara, Shoichiro
Hirayama, Takeshi
Ikegami, Tadashi
Honda, Akira
Matsuzaki, Yasushi
Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title_full Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title_fullStr Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title_full_unstemmed Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title_short Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
title_sort effects of the concomitant use of low-dose clarithromycin with an anti-tnfα antibody in a patient with intestinal behçet disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827312/
https://www.ncbi.nlm.nih.gov/pubmed/29093413
http://dx.doi.org/10.2169/internalmedicine.9322-17
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