Prednisolone-responsive Postpartum IgG4-related Hypophysitis

We herein report the case of a 25-year-old woman who presented with severe headache and visual field defects after childbirth. Magnetic resonance imaging revealed marked swelling of the pituitary gland, and an endocrinological examination revealed panhypopituitarism and diabetes insipidus. An immuno...

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Detalles Bibliográficos
Autores principales: Koide, Hisashi, Shiga, Akina, Komai, Eri, Yamato, Azusa, Fujimoto, Masanori, Tamura, Ai, Kono, Takashi, Nakayama, Akitoshi, Takiguchi, Tomoko, Higuchi, Seiichiro, Sakuma, Ikki, Nagano, Hidekazu, Hashimoto, Naoko, Suzuki, Sawako, Takeda, Yasuaki, Shibuya, Makoto, Nishioka, Hiroshi, Yamada, Shozo, Inoshita, Naoko, Ishiwatari, Norio, Horiguchi, Kentaro, Yokote, Koutaro, Tanaka, Tomoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827318/
https://www.ncbi.nlm.nih.gov/pubmed/29093382
http://dx.doi.org/10.2169/internalmedicine.8446-16
Descripción
Sumario:We herein report the case of a 25-year-old woman who presented with severe headache and visual field defects after childbirth. Magnetic resonance imaging revealed marked swelling of the pituitary gland, and an endocrinological examination revealed panhypopituitarism and diabetes insipidus. An immunohistological analysis of a transsphenoidal biopsy sample of the pituitary gland showed the significant accumulation of an immunogloblin G4 (IgG4)-positive population, leading to the diagnosis of IgG4-related hypophysitis. The patient was treated with prednisolone, which markedly reduced the swelling of the pituitary gland, in association with recovery of the pituitary function. This is a rare case of biopsy-proven IgG4-related hypophysitis with a postpartum onset.

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