Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients

A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pn...

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Autores principales: Sone, Kazuki, Muramatsu, Hideki, Nakao, Makoto, Kagawa, Yusuke, Kurokawa, Ryota, Sato, Hidefumi, Niimi, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827320/
https://www.ncbi.nlm.nih.gov/pubmed/29093385
http://dx.doi.org/10.2169/internalmedicine.8746-16
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author Sone, Kazuki
Muramatsu, Hideki
Nakao, Makoto
Kagawa, Yusuke
Kurokawa, Ryota
Sato, Hidefumi
Niimi, Akio
author_facet Sone, Kazuki
Muramatsu, Hideki
Nakao, Makoto
Kagawa, Yusuke
Kurokawa, Ryota
Sato, Hidefumi
Niimi, Akio
author_sort Sone, Kazuki
collection PubMed
description A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL). Despite intensive work-up, we were unable to detect the underlying cause of CD4+ lymphocytopenia; therefore, a final diagnosis of idiopathic CD4+ T-lymphocytopenia was made.
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spelling pubmed-58273202018-02-28 Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients Sone, Kazuki Muramatsu, Hideki Nakao, Makoto Kagawa, Yusuke Kurokawa, Ryota Sato, Hidefumi Niimi, Akio Intern Med Case Report A 67-year-old man was admitted to our hospital complaining of dry cough. Chest computed tomography showed diffuse infiltrates and ground-glass opacities in the bilateral lung fields. Transbronchial lung biopsy specimens showed alveoli filled with yeast-like fungi. With a diagnosis of pneumocystis pneumonia (PCP), he was given oral sulfamethoxazole/trimethoprim, to which he responded well. However, seven months later, PCP relapsed. Analyses revealed a low bronchoalveolar lavage fluid CD4/CD8 ratio of 0.04 and CD4+ lymphocytopenia (250/μL). Despite intensive work-up, we were unable to detect the underlying cause of CD4+ lymphocytopenia; therefore, a final diagnosis of idiopathic CD4+ T-lymphocytopenia was made. The Japanese Society of Internal Medicine 2017-11-01 2018-02-01 /pmc/articles/PMC5827320/ /pubmed/29093385 http://dx.doi.org/10.2169/internalmedicine.8746-16 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sone, Kazuki
Muramatsu, Hideki
Nakao, Makoto
Kagawa, Yusuke
Kurokawa, Ryota
Sato, Hidefumi
Niimi, Akio
Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title_full Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title_fullStr Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title_full_unstemmed Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title_short Pneumocystis Pneumonia Secondary to Idiopathic CD4+ T-lymphocytopenia: A Comparison of AIDS and Non-AIDS Patients
title_sort pneumocystis pneumonia secondary to idiopathic cd4+ t-lymphocytopenia: a comparison of aids and non-aids patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827320/
https://www.ncbi.nlm.nih.gov/pubmed/29093385
http://dx.doi.org/10.2169/internalmedicine.8746-16
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