The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level

We report the case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-melanoma differentiation-associated gene 5 (MDA5) antibody levels were elevated at the time of admission. Despite intensive t...

Descripción completa

Detalles Bibliográficos
Autores principales: Osawa, Takeshi, Morimoto, Kozo, Sasaki, Yuka, Matsuda, Shuichi, Yamana, Kazunari, Yano, Ryozo, Uchiyama, Takashi, Goto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827321/
https://www.ncbi.nlm.nih.gov/pubmed/29093381
http://dx.doi.org/10.2169/internalmedicine.8335-16
_version_ 1783302455299145728
author Osawa, Takeshi
Morimoto, Kozo
Sasaki, Yuka
Matsuda, Shuichi
Yamana, Kazunari
Yano, Ryozo
Uchiyama, Takashi
Goto, Hajime
author_facet Osawa, Takeshi
Morimoto, Kozo
Sasaki, Yuka
Matsuda, Shuichi
Yamana, Kazunari
Yano, Ryozo
Uchiyama, Takashi
Goto, Hajime
author_sort Osawa, Takeshi
collection PubMed
description We report the case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-melanoma differentiation-associated gene 5 (MDA5) antibody levels were elevated at the time of admission. Despite intensive treatment with corticosteroids, immunosuppressants, immunoglobulins and polymyxin B direct hemoperfusion, the patient died 75 days after symptom onset. Over the course of treatment, the anti-MDA5 antibody level continually decreased, while the serum ferritin level increased, suggesting that sequential measurements of the serum ferritin level might be useful for evaluating the treatment responsivity, irrespective of the anti-MDA5 antibody level.
format Online
Article
Text
id pubmed-5827321
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-58273212018-02-28 The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level Osawa, Takeshi Morimoto, Kozo Sasaki, Yuka Matsuda, Shuichi Yamana, Kazunari Yano, Ryozo Uchiyama, Takashi Goto, Hajime Intern Med Case Report We report the case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-melanoma differentiation-associated gene 5 (MDA5) antibody levels were elevated at the time of admission. Despite intensive treatment with corticosteroids, immunosuppressants, immunoglobulins and polymyxin B direct hemoperfusion, the patient died 75 days after symptom onset. Over the course of treatment, the anti-MDA5 antibody level continually decreased, while the serum ferritin level increased, suggesting that sequential measurements of the serum ferritin level might be useful for evaluating the treatment responsivity, irrespective of the anti-MDA5 antibody level. The Japanese Society of Internal Medicine 2017-11-01 2018-02-01 /pmc/articles/PMC5827321/ /pubmed/29093381 http://dx.doi.org/10.2169/internalmedicine.8335-16 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Osawa, Takeshi
Morimoto, Kozo
Sasaki, Yuka
Matsuda, Shuichi
Yamana, Kazunari
Yano, Ryozo
Uchiyama, Takashi
Goto, Hajime
The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title_full The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title_fullStr The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title_full_unstemmed The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title_short The Serum Ferritin Level Is Associated with the Treatment Responsivity for Rapidly Progressive Interstitial Lung Disease with Amyopathic Dermatomyositis, Irrespective of the Anti-MDA5 Antibody Level
title_sort serum ferritin level is associated with the treatment responsivity for rapidly progressive interstitial lung disease with amyopathic dermatomyositis, irrespective of the anti-mda5 antibody level
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827321/
https://www.ncbi.nlm.nih.gov/pubmed/29093381
http://dx.doi.org/10.2169/internalmedicine.8335-16
work_keys_str_mv AT osawatakeshi theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT morimotokozo theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT sasakiyuka theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT matsudashuichi theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT yamanakazunari theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT yanoryozo theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT uchiyamatakashi theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT gotohajime theserumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT osawatakeshi serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT morimotokozo serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT sasakiyuka serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT matsudashuichi serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT yamanakazunari serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT yanoryozo serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT uchiyamatakashi serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel
AT gotohajime serumferritinlevelisassociatedwiththetreatmentresponsivityforrapidlyprogressiveinterstitiallungdiseasewithamyopathicdermatomyositisirrespectiveoftheantimda5antibodylevel

Ejemplares similares