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High Titer of Acquired Factor V Inhibitor Presenting with a Pseudo-deficiency of Multiple Coagulation Factors

Acquired coagulation factor inhibitor is a rare coagulation disorder. We herein report a patient with acquired factor V inhibitor showing a decrease in multiple coagulation factor activities. A high titer of factor V inhibitor presumably led to a marked inhibition of factor V activity in the specifi...

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Detalles Bibliográficos
Autores principales: Nakata, Keiichi, Ueda, Shuji, Matsunaga, Hitomi, Mima, Fuka, Ueda, Hiroki, Yoshioka, Aya, Kaneko, Sayoko, Maruo, Kazushi, Morris, Shayne, Yonemoto, Sayoko, Hayashi, Daisuke, Fujii, Naohiko, Narahara, Hiroyuki, Inui, Yoshiaki, Kawata, Sumio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827322/
https://www.ncbi.nlm.nih.gov/pubmed/29093398
http://dx.doi.org/10.2169/internalmedicine.9150-17
Descripción
Sumario:Acquired coagulation factor inhibitor is a rare coagulation disorder. We herein report a patient with acquired factor V inhibitor showing a decrease in multiple coagulation factor activities. A high titer of factor V inhibitor presumably led to a marked inhibition of factor V activity in the specific factor-deficient plasma used in coagulation factor activity assays based on either an activated partial thromboplastin time (APTT) or prothrombin time (PT) clotting assay, resulting in false low values of the coagulation activity. We re-examined the coagulation factor activity using several dilutions of the patient's plasma and confirmed that the high factor V inhibitor titer had caused an apparent decrease in multiple coagulation factor activities.