The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman

A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevat...

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Autores principales: Nakamura, Yuya, Ohsawa, Isao, Goto, Yoshikazu, Namba, Hokuto, Dodo, Yusuke, Tsuji, Mayumi, Kiuchi, Yuji, Inagaki, Masahiro, Gotoh, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827324/
https://www.ncbi.nlm.nih.gov/pubmed/29093386
http://dx.doi.org/10.2169/internalmedicine.8809-17
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author Nakamura, Yuya
Ohsawa, Isao
Goto, Yoshikazu
Namba, Hokuto
Dodo, Yusuke
Tsuji, Mayumi
Kiuchi, Yuji
Inagaki, Masahiro
Gotoh, Hiromichi
author_facet Nakamura, Yuya
Ohsawa, Isao
Goto, Yoshikazu
Namba, Hokuto
Dodo, Yusuke
Tsuji, Mayumi
Kiuchi, Yuji
Inagaki, Masahiro
Gotoh, Hiromichi
author_sort Nakamura, Yuya
collection PubMed
description A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection. After providing supportive treatment, the heart failure symptoms disappeared and her anemia had improved. This case emphasizes the need to include a B19V infection in the differential diagnosis when we encounter cases demonstrating reversible heart failure with anemia.
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spelling pubmed-58273242018-02-28 The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman Nakamura, Yuya Ohsawa, Isao Goto, Yoshikazu Namba, Hokuto Dodo, Yusuke Tsuji, Mayumi Kiuchi, Yuji Inagaki, Masahiro Gotoh, Hiromichi Intern Med Case Report A 35-year-old woman with fever, edema and rash was admitted. Pleural effusion and cardiomegaly were observed. A laboratory analysis revealed anemia with iron deficiency and elevated human parvovirus B19 (B19V) immunoglobulin M. The patient's hepcidin-25 and erythroferrone levels were not elevated compared to those observed later in her clinical course. On the other hand, her growth differentiation factor-15 (GDF-15) levels were elevated. She was diagnosed to have heart failure symptoms and anemia with specific iron metabolism abnormalities due to a B19V infection. After providing supportive treatment, the heart failure symptoms disappeared and her anemia had improved. This case emphasizes the need to include a B19V infection in the differential diagnosis when we encounter cases demonstrating reversible heart failure with anemia. The Japanese Society of Internal Medicine 2017-11-01 2018-02-01 /pmc/articles/PMC5827324/ /pubmed/29093386 http://dx.doi.org/10.2169/internalmedicine.8809-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakamura, Yuya
Ohsawa, Isao
Goto, Yoshikazu
Namba, Hokuto
Dodo, Yusuke
Tsuji, Mayumi
Kiuchi, Yuji
Inagaki, Masahiro
Gotoh, Hiromichi
The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title_full The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title_fullStr The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title_full_unstemmed The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title_short The Impact of Human Parvovirus B19 Infection on Heart Failure and Anemia with Reference to Iron Metabolism Markers in an Adult Woman
title_sort impact of human parvovirus b19 infection on heart failure and anemia with reference to iron metabolism markers in an adult woman
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827324/
https://www.ncbi.nlm.nih.gov/pubmed/29093386
http://dx.doi.org/10.2169/internalmedicine.8809-17
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