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Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein

The heterodimeric human (h) electron-transferring flavoprotein (ETF) transfers electrons from at least 13 different flavin dehydrogenases to the mitochondrial respiratory chain through a non-covalently bound FAD cofactor. Here, we describe the discovery of an irreversible and pH-dependent oxidation...

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Detalles Bibliográficos
Autores principales:	Augustin, Peter, Toplak, Marina, Fuchs, Katharina, Gerstmann, Eva Christine, Prassl, Ruth, Winkler, Andreas, Macheroux, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827430/ https://www.ncbi.nlm.nih.gov/pubmed/29301933 http://dx.doi.org/10.1074/jbc.RA117.000846

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