Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)

In article number https://doi.org/10.1002/advs.201700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers...

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Detalles Bibliográficos
Autores principales: Dou, Ce, Ding, Ning, Luo, Fei, Hou, Tianyong, Cao, Zhen, Bai, Yun, Liu, Chuan, Xu, Jianzhong, Dong, Shiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827466/
http://dx.doi.org/10.1002/advs.201870009
Descripción
Sumario:In article number https://doi.org/10.1002/advs.201700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers the miR‐7b plasmid into bone marrow macrophases and reduces the expression of target protein dendritic cell‐specific transmembrane protein, specifically targeting cell–cell fusion to block the formation of mature osteoclasts while preserving beneficial preosteoclasts. [Image: see text]

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