Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)

In article number https://doi.org/10.1002/advs.201700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers...

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Detalles Bibliográficos
Autores principales: Dou, Ce, Ding, Ning, Luo, Fei, Hou, Tianyong, Cao, Zhen, Bai, Yun, Liu, Chuan, Xu, Jianzhong, Dong, Shiwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827466/
http://dx.doi.org/10.1002/advs.201870009
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author Dou, Ce
Ding, Ning
Luo, Fei
Hou, Tianyong
Cao, Zhen
Bai, Yun
Liu, Chuan
Xu, Jianzhong
Dong, Shiwu
author_facet Dou, Ce
Ding, Ning
Luo, Fei
Hou, Tianyong
Cao, Zhen
Bai, Yun
Liu, Chuan
Xu, Jianzhong
Dong, Shiwu
author_sort Dou, Ce
collection PubMed
description In article number https://doi.org/10.1002/advs.201700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers the miR‐7b plasmid into bone marrow macrophases and reduces the expression of target protein dendritic cell‐specific transmembrane protein, specifically targeting cell–cell fusion to block the formation of mature osteoclasts while preserving beneficial preosteoclasts. [Image: see text]
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spelling pubmed-58274662018-04-04 Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018) Dou, Ce Ding, Ning Luo, Fei Hou, Tianyong Cao, Zhen Bai, Yun Liu, Chuan Xu, Jianzhong Dong, Shiwu Adv Sci (Weinh) Frontispiece In article number https://doi.org/10.1002/advs.201700578, Jianzhong Xu, Shiwu Dong, and co‐workers report the development of a graphene‐based miRNA transfection system that uses a polyethylenimine (PEI) functionalized graphene oxide complex loaded with miR‐7b plasmid. The system efficiently delivers the miR‐7b plasmid into bone marrow macrophases and reduces the expression of target protein dendritic cell‐specific transmembrane protein, specifically targeting cell–cell fusion to block the formation of mature osteoclasts while preserving beneficial preosteoclasts. [Image: see text] John Wiley and Sons Inc. 2018-02-27 /pmc/articles/PMC5827466/ http://dx.doi.org/10.1002/advs.201870009 Text en © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Dou, Ce
Ding, Ning
Luo, Fei
Hou, Tianyong
Cao, Zhen
Bai, Yun
Liu, Chuan
Xu, Jianzhong
Dong, Shiwu
Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title_full Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title_fullStr Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title_full_unstemmed Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title_short Drug Delivery: Graphene‐Based MicroRNA Transfection Blocks Preosteoclast Fusion to Increase Bone Formation and Vascularization (Adv. Sci. 2/2018)
title_sort drug delivery: graphene‐based microrna transfection blocks preosteoclast fusion to increase bone formation and vascularization (adv. sci. 2/2018)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827466/
http://dx.doi.org/10.1002/advs.201870009
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