Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)

The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number https://doi.org/...

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Detalles Bibliográficos
Autores principales: Fan, Li, Zhang, Silu, Zhang, Chunyuan, Yin, Chun, Chu, Zhiqin, Song, Chaojun, Lin, Ge, Li, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827468/
http://dx.doi.org/10.1002/advs.201870006
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author Fan, Li
Zhang, Silu
Zhang, Chunyuan
Yin, Chun
Chu, Zhiqin
Song, Chaojun
Lin, Ge
Li, Quan
author_facet Fan, Li
Zhang, Silu
Zhang, Chunyuan
Yin, Chun
Chu, Zhiqin
Song, Chaojun
Lin, Ge
Li, Quan
author_sort Fan, Li
collection PubMed
description The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number https://doi.org/10.1002/advs.201700289, Quan Li and co‐workers demonstrate the feasibility of using self‐decomposable nanoparticle drug carriers as intracellular drug reservoirs that enable delivery of a stable therapeutic concentration, leading to complete reversal of multidrug resistance. [Image: see text]
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spelling pubmed-58274682018-04-04 Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018) Fan, Li Zhang, Silu Zhang, Chunyuan Yin, Chun Chu, Zhiqin Song, Chaojun Lin, Ge Li, Quan Adv Sci (Weinh) Cover Picture The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number https://doi.org/10.1002/advs.201700289, Quan Li and co‐workers demonstrate the feasibility of using self‐decomposable nanoparticle drug carriers as intracellular drug reservoirs that enable delivery of a stable therapeutic concentration, leading to complete reversal of multidrug resistance. [Image: see text] John Wiley and Sons Inc. 2018-02-27 /pmc/articles/PMC5827468/ http://dx.doi.org/10.1002/advs.201870006 Text en © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Fan, Li
Zhang, Silu
Zhang, Chunyuan
Yin, Chun
Chu, Zhiqin
Song, Chaojun
Lin, Ge
Li, Quan
Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title_full Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title_fullStr Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title_full_unstemmed Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title_short Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
title_sort drug delivery: multidrug resistance in cancer circumvented using a cytosolic drug reservoir (adv. sci. 2/2018)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827468/
http://dx.doi.org/10.1002/advs.201870006
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