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Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study

CONTEXT: Host modulation with omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has anti-inflammatory and pro-resolution actions through replacing and inhibiting metabolism of arachidonic acid (AA). AIM: This study was aimed at evaluating clinical parameters and salivary levels of interleukin-1 beta (...

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Autores principales: Umrania, Vanali Vinodbhai, Rao Deepika, Pawar Chandrashekara, Kulkarni, Madhuri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827506/
https://www.ncbi.nlm.nih.gov/pubmed/29491585
http://dx.doi.org/10.4103/jisp.jisp_16_16
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author Umrania, Vanali Vinodbhai
Rao Deepika, Pawar Chandrashekara
Kulkarni, Madhuri
author_facet Umrania, Vanali Vinodbhai
Rao Deepika, Pawar Chandrashekara
Kulkarni, Madhuri
author_sort Umrania, Vanali Vinodbhai
collection PubMed
description CONTEXT: Host modulation with omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has anti-inflammatory and pro-resolution actions through replacing and inhibiting metabolism of arachidonic acid (AA). AIM: This study was aimed at evaluating clinical parameters and salivary levels of interleukin-1 beta (IL-1β) after scaling and root planing (SRP) in chronic periodontitis patients, with and without dietary supplementation of ω-3 PUFAs. SETTINGS AND DESIGN: Forty otherwise healthy participants with severe chronic periodontitis were included. Full-mouth periodontal examination and scaling and root planing were done for test and control group (20 participants each). MATERIALS AND METHODS: The control group received SRP alone while test group received daily dose of 700 mg ω-3 PUFA capsules for 3 months. All clinical parameters were checked at baseline, 1 month, and 3 months' duration, whereas levels of IL-1β were checked in saliva at baseline and 3 months after therapy. STATISTICAL ANALYSIS USED: T-test and repeated measure analysis of variance were used with Statistical Package for the Social Science Windows software. RESULTS: Improvements in all clinical outcomes were similar in both groups over 3 months. Improvements in clinical parameters were not statistically significant on intergroup comparison, except for improvement in Bleeding Index and reduction in levels of IL-1β, which were statistically significant in test group as compared to control group (P < 0.05). CONCLUSION: Even though adjunct therapy with ω-3 PUFAs can modulate cytokine levels and show proresolution properties, its importance on clinical outcomes may be controversial. Thus, this may be used as an adjunctive management of chronic periodontitis.
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spelling pubmed-58275062018-02-28 Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study Umrania, Vanali Vinodbhai Rao Deepika, Pawar Chandrashekara Kulkarni, Madhuri J Indian Soc Periodontol Original Article CONTEXT: Host modulation with omega-3 polyunsaturated fatty acids (ω-3 PUFAs) has anti-inflammatory and pro-resolution actions through replacing and inhibiting metabolism of arachidonic acid (AA). AIM: This study was aimed at evaluating clinical parameters and salivary levels of interleukin-1 beta (IL-1β) after scaling and root planing (SRP) in chronic periodontitis patients, with and without dietary supplementation of ω-3 PUFAs. SETTINGS AND DESIGN: Forty otherwise healthy participants with severe chronic periodontitis were included. Full-mouth periodontal examination and scaling and root planing were done for test and control group (20 participants each). MATERIALS AND METHODS: The control group received SRP alone while test group received daily dose of 700 mg ω-3 PUFA capsules for 3 months. All clinical parameters were checked at baseline, 1 month, and 3 months' duration, whereas levels of IL-1β were checked in saliva at baseline and 3 months after therapy. STATISTICAL ANALYSIS USED: T-test and repeated measure analysis of variance were used with Statistical Package for the Social Science Windows software. RESULTS: Improvements in all clinical outcomes were similar in both groups over 3 months. Improvements in clinical parameters were not statistically significant on intergroup comparison, except for improvement in Bleeding Index and reduction in levels of IL-1β, which were statistically significant in test group as compared to control group (P < 0.05). CONCLUSION: Even though adjunct therapy with ω-3 PUFAs can modulate cytokine levels and show proresolution properties, its importance on clinical outcomes may be controversial. Thus, this may be used as an adjunctive management of chronic periodontitis. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5827506/ /pubmed/29491585 http://dx.doi.org/10.4103/jisp.jisp_16_16 Text en Copyright: © 2018 Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Umrania, Vanali Vinodbhai
Rao Deepika, Pawar Chandrashekara
Kulkarni, Madhuri
Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title_full Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title_fullStr Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title_full_unstemmed Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title_short Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
title_sort evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: a clinico-immunological study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827506/
https://www.ncbi.nlm.nih.gov/pubmed/29491585
http://dx.doi.org/10.4103/jisp.jisp_16_16
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