Clonally diverse CD38(+)HLA-DR(+)CD8(+) T cells persist during fatal H7N9 disease

Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8(+) T-cell profiles from patients hospitalized with avian H7N9, seasonal IAV, and influenza vaccinees. Patient survival reflects an early, transient prevalence of highly activated CD38(+)HLA-...

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Detalles Bibliográficos
Autores principales: Wang, Zhongfang, Zhu, Lingyan, Nguyen, Thi H. O., Wan, Yanmin, Sant, Sneha, Quiñones-Parra, Sergio M., Crawford, Jeremy Chase, Eltahla, Auda A., Rizzetto, Simone, Bull, Rowena A., Qiu, Chenli, Koutsakos, Marios, Clemens, E. Bridie, Loh, Liyen, Chen, Tianyue, Liu, Lu, Cao, Pengxing, Ren, Yanqin, Kedzierski, Lukasz, Kotsimbos, Tom, McCaw, James M., La Gruta, Nicole L., Turner, Stephen J., Cheng, Allen C., Luciani, Fabio, Zhang, Xiaoyan, Doherty, Peter C., Thomas, Paul G., Xu, Jianqing, Kedzierska, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827521/
https://www.ncbi.nlm.nih.gov/pubmed/29483513
http://dx.doi.org/10.1038/s41467-018-03243-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827521/
https://www.ncbi.nlm.nih.gov/pubmed/29483513
http://dx.doi.org/10.1038/s41467-018-03243-7

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