Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis

One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Rec...

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Autores principales: Kasperkiewicz, Michael, Schmidt, Enno, Ludwig, Ralf J., Zillikens, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827554/
https://www.ncbi.nlm.nih.gov/pubmed/29520268
http://dx.doi.org/10.3389/fimmu.2018.00254
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author Kasperkiewicz, Michael
Schmidt, Enno
Ludwig, Ralf J.
Zillikens, Detlef
author_facet Kasperkiewicz, Michael
Schmidt, Enno
Ludwig, Ralf J.
Zillikens, Detlef
author_sort Kasperkiewicz, Michael
collection PubMed
description One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Recent reports proposed the use of IA also for patients with severe AD and high total serum IgE levels. In this mini-review, we summarize the current knowledge about this novel treatment approach for AD and briefly discuss the so far incompletely known role of autoreactive IgE as potential target of IA therapy in this common inflammatory skin disorder.
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spelling pubmed-58275542018-03-08 Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis Kasperkiewicz, Michael Schmidt, Enno Ludwig, Ralf J. Zillikens, Detlef Front Immunol Immunology One major hallmark of atopic dermatitis (AD) is the elevated level of total serum IgE, which has been reported to be partly of the autoreactive type in a subset of patients. Immunoadsorption (IA) has been successfully applied in various classical autoantibody-mediated diseases such as pemphigus. Recent reports proposed the use of IA also for patients with severe AD and high total serum IgE levels. In this mini-review, we summarize the current knowledge about this novel treatment approach for AD and briefly discuss the so far incompletely known role of autoreactive IgE as potential target of IA therapy in this common inflammatory skin disorder. Frontiers Media S.A. 2018-02-19 /pmc/articles/PMC5827554/ /pubmed/29520268 http://dx.doi.org/10.3389/fimmu.2018.00254 Text en Copyright © 2018 Kasperkiewicz, Schmidt, Ludwig and Zillikens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kasperkiewicz, Michael
Schmidt, Enno
Ludwig, Ralf J.
Zillikens, Detlef
Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title_full Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title_fullStr Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title_full_unstemmed Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title_short Targeting IgE Antibodies by Immunoadsorption in Atopic Dermatitis
title_sort targeting ige antibodies by immunoadsorption in atopic dermatitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827554/
https://www.ncbi.nlm.nih.gov/pubmed/29520268
http://dx.doi.org/10.3389/fimmu.2018.00254
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AT ludwigralfj targetingigeantibodiesbyimmunoadsorptioninatopicdermatitis
AT zillikensdetlef targetingigeantibodiesbyimmunoadsorptioninatopicdermatitis

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