Lkb1 deficiency confers glutamine dependency in polycystic kidney disease

Polycystic kidney disease (PKD) is a common genetic disorder characterized by the growth of fluid-filled cysts in the kidneys. Several studies reported that the serine-threonine kinase Lkb1 is dysregulated in PKD. Here we show that genetic ablation of Lkb1 in the embryonic ureteric bud has no effect...

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Detalles Bibliográficos
Autores principales: Flowers, Ebony M., Sudderth, Jessica, Zacharias, Lauren, Mernaugh, Glenda, Zent, Roy, DeBerardinis, Ralph J., Carroll, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827653/
https://www.ncbi.nlm.nih.gov/pubmed/29483507
http://dx.doi.org/10.1038/s41467-018-03036-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827653/
https://www.ncbi.nlm.nih.gov/pubmed/29483507
http://dx.doi.org/10.1038/s41467-018-03036-y

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