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IGF-I induced phosphorylation of PTH receptor enhances osteoblast to osteocyte transition

Parathyroid hormone (PTH) regulates bone remodeling by activating PTH type 1 receptor (PTH1R) in osteoblasts/osteocytes. Insulin-like growth factor type 1 (IGF-1) stimulates mesenchymal stem cell differentiation to osteoblasts. However, little is known about the signaling mechanisms that regulates t...

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Detalles Bibliográficos
Autores principales: Qiu, Tao, Crane, Janet L., Xie, Liang, Xian, Lingling, Xie, Hui, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827661/
https://www.ncbi.nlm.nih.gov/pubmed/29507819
http://dx.doi.org/10.1038/s41413-017-0002-7