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Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats

Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials an...

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Autores principales: Kading, Rebekah C., Kityo, Robert M., Mossel, Eric C., Borland, Erin M., Nakayiki, Teddie, Nalikka, Betty, Nyakarahuka, Luke, Ledermann, Jeremy P., Panella, Nicholas A., Gilbert, Amy T., Crabtree, Mary B., Peterhans, Julian Kerbis, Towner, Jonathan S., Amman, Brian R., Sealy, Tara K., Nichol, Stuart T., Powers, Ann M., Lutwama, Julius J., Miller, Barry R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827769/
https://www.ncbi.nlm.nih.gov/pubmed/29511459
http://dx.doi.org/10.1080/20008686.2018.1439215
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author Kading, Rebekah C.
Kityo, Robert M.
Mossel, Eric C.
Borland, Erin M.
Nakayiki, Teddie
Nalikka, Betty
Nyakarahuka, Luke
Ledermann, Jeremy P.
Panella, Nicholas A.
Gilbert, Amy T.
Crabtree, Mary B.
Peterhans, Julian Kerbis
Towner, Jonathan S.
Amman, Brian R.
Sealy, Tara K.
Nichol, Stuart T.
Powers, Ann M.
Lutwama, Julius J.
Miller, Barry R.
author_facet Kading, Rebekah C.
Kityo, Robert M.
Mossel, Eric C.
Borland, Erin M.
Nakayiki, Teddie
Nalikka, Betty
Nyakarahuka, Luke
Ledermann, Jeremy P.
Panella, Nicholas A.
Gilbert, Amy T.
Crabtree, Mary B.
Peterhans, Julian Kerbis
Towner, Jonathan S.
Amman, Brian R.
Sealy, Tara K.
Nichol, Stuart T.
Powers, Ann M.
Lutwama, Julius J.
Miller, Barry R.
author_sort Kading, Rebekah C.
collection PubMed
description Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials and methods: Insectivorous and fruit bats were captured from multiple locations throughout Uganda during 2009 and 2011–2013. All serum samples were tested for neutralizing antibodies against West Nile virus (WNV), yellow fever virus (YFV), dengue 2 virus (DENV-2), Zika virus (ZIKV), Babanki virus (BBKV), and Rift Valley fever virus (RVFV) by plaque reduction neutralization test (PRNT). Sera from up to 626 bats were screened for antibodies against each virus. Results and Discussion: Key findings include the presence of neutralizing antibodies against RVFV in 5/52 (9.6%) of little epauletted fruit bats (Epomophorus labiatus) captured from Kawuku and 3/54 (5.6%) Egyptian rousette bats from Kasokero cave. Antibodies reactive to flaviviruses were widespread across bat taxa and sampling locations. Conclusion: The data presented demonstrate the widespread exposure of bats in Uganda to arboviruses, and highlight particular virus-bat associations that warrant further investigation.
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spelling pubmed-58277692018-03-06 Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats Kading, Rebekah C. Kityo, Robert M. Mossel, Eric C. Borland, Erin M. Nakayiki, Teddie Nalikka, Betty Nyakarahuka, Luke Ledermann, Jeremy P. Panella, Nicholas A. Gilbert, Amy T. Crabtree, Mary B. Peterhans, Julian Kerbis Towner, Jonathan S. Amman, Brian R. Sealy, Tara K. Nichol, Stuart T. Powers, Ann M. Lutwama, Julius J. Miller, Barry R. Infect Ecol Epidemiol Research Article Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials and methods: Insectivorous and fruit bats were captured from multiple locations throughout Uganda during 2009 and 2011–2013. All serum samples were tested for neutralizing antibodies against West Nile virus (WNV), yellow fever virus (YFV), dengue 2 virus (DENV-2), Zika virus (ZIKV), Babanki virus (BBKV), and Rift Valley fever virus (RVFV) by plaque reduction neutralization test (PRNT). Sera from up to 626 bats were screened for antibodies against each virus. Results and Discussion: Key findings include the presence of neutralizing antibodies against RVFV in 5/52 (9.6%) of little epauletted fruit bats (Epomophorus labiatus) captured from Kawuku and 3/54 (5.6%) Egyptian rousette bats from Kasokero cave. Antibodies reactive to flaviviruses were widespread across bat taxa and sampling locations. Conclusion: The data presented demonstrate the widespread exposure of bats in Uganda to arboviruses, and highlight particular virus-bat associations that warrant further investigation. Taylor & Francis 2018-02-21 /pmc/articles/PMC5827769/ /pubmed/29511459 http://dx.doi.org/10.1080/20008686.2018.1439215 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kading, Rebekah C.
Kityo, Robert M.
Mossel, Eric C.
Borland, Erin M.
Nakayiki, Teddie
Nalikka, Betty
Nyakarahuka, Luke
Ledermann, Jeremy P.
Panella, Nicholas A.
Gilbert, Amy T.
Crabtree, Mary B.
Peterhans, Julian Kerbis
Towner, Jonathan S.
Amman, Brian R.
Sealy, Tara K.
Nichol, Stuart T.
Powers, Ann M.
Lutwama, Julius J.
Miller, Barry R.
Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title_full Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title_fullStr Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title_full_unstemmed Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title_short Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats
title_sort neutralizing antibodies against flaviviruses, babanki virus, and rift valley fever virus in ugandan bats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827769/
https://www.ncbi.nlm.nih.gov/pubmed/29511459
http://dx.doi.org/10.1080/20008686.2018.1439215
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