Cargando…
Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828052/ https://www.ncbi.nlm.nih.gov/pubmed/29607329 http://dx.doi.org/10.1155/2018/9815806 |
_version_ | 1783302563499606016 |
---|---|
author | Liu, Ying Cui, Jian Tang, Yun-Liang Huang, Liang Zhou, Cong-Yang Xu, Ji-Xiong |
author_facet | Liu, Ying Cui, Jian Tang, Yun-Liang Huang, Liang Zhou, Cong-Yang Xu, Ji-Xiong |
author_sort | Liu, Ying |
collection | PubMed |
description | The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan–Meier plotter (KM plotter) database. Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma. In particular, high mRNA expression level of S100B was associated with better OS in NSCLC patients. The prognostic value of S100 according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of NSCLC was further assessed. Although the results should be further verified in clinical trials our findings provide new insights into the prognostic roles of S100 proteins in NSCLC and might promote development of S100-targeted inhibitors for the treatment of NSCLC. |
format | Online Article Text |
id | pubmed-5828052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58280522018-04-01 Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer Liu, Ying Cui, Jian Tang, Yun-Liang Huang, Liang Zhou, Cong-Yang Xu, Ji-Xiong Biomed Res Int Research Article The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan–Meier plotter (KM plotter) database. Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma. In particular, high mRNA expression level of S100B was associated with better OS in NSCLC patients. The prognostic value of S100 according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of NSCLC was further assessed. Although the results should be further verified in clinical trials our findings provide new insights into the prognostic roles of S100 proteins in NSCLC and might promote development of S100-targeted inhibitors for the treatment of NSCLC. Hindawi 2018-01-21 /pmc/articles/PMC5828052/ /pubmed/29607329 http://dx.doi.org/10.1155/2018/9815806 Text en Copyright © 2018 Ying Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Ying Cui, Jian Tang, Yun-Liang Huang, Liang Zhou, Cong-Yang Xu, Ji-Xiong Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title | Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title_full | Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title_fullStr | Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title_full_unstemmed | Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title_short | Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer |
title_sort | prognostic roles of mrna expression of s100 in non-small-cell lung cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828052/ https://www.ncbi.nlm.nih.gov/pubmed/29607329 http://dx.doi.org/10.1155/2018/9815806 |
work_keys_str_mv | AT liuying prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer AT cuijian prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer AT tangyunliang prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer AT huangliang prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer AT zhoucongyang prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer AT xujixiong prognosticrolesofmrnaexpressionofs100innonsmallcelllungcancer |