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Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer

The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan...

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Autores principales: Liu, Ying, Cui, Jian, Tang, Yun-Liang, Huang, Liang, Zhou, Cong-Yang, Xu, Ji-Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828052/
https://www.ncbi.nlm.nih.gov/pubmed/29607329
http://dx.doi.org/10.1155/2018/9815806
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author Liu, Ying
Cui, Jian
Tang, Yun-Liang
Huang, Liang
Zhou, Cong-Yang
Xu, Ji-Xiong
author_facet Liu, Ying
Cui, Jian
Tang, Yun-Liang
Huang, Liang
Zhou, Cong-Yang
Xu, Ji-Xiong
author_sort Liu, Ying
collection PubMed
description The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan–Meier plotter (KM plotter) database. Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma. In particular, high mRNA expression level of S100B was associated with better OS in NSCLC patients. The prognostic value of S100 according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of NSCLC was further assessed. Although the results should be further verified in clinical trials our findings provide new insights into the prognostic roles of S100 proteins in NSCLC and might promote development of S100-targeted inhibitors for the treatment of NSCLC.
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spelling pubmed-58280522018-04-01 Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer Liu, Ying Cui, Jian Tang, Yun-Liang Huang, Liang Zhou, Cong-Yang Xu, Ji-Xiong Biomed Res Int Research Article The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan–Meier plotter (KM plotter) database. Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma. In particular, high mRNA expression level of S100B was associated with better OS in NSCLC patients. The prognostic value of S100 according to smoking status, pathological grades, clinical stages, and chemotherapeutic treatment of NSCLC was further assessed. Although the results should be further verified in clinical trials our findings provide new insights into the prognostic roles of S100 proteins in NSCLC and might promote development of S100-targeted inhibitors for the treatment of NSCLC. Hindawi 2018-01-21 /pmc/articles/PMC5828052/ /pubmed/29607329 http://dx.doi.org/10.1155/2018/9815806 Text en Copyright © 2018 Ying Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Ying
Cui, Jian
Tang, Yun-Liang
Huang, Liang
Zhou, Cong-Yang
Xu, Ji-Xiong
Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title_full Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title_fullStr Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title_full_unstemmed Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title_short Prognostic Roles of mRNA Expression of S100 in Non-Small-Cell Lung Cancer
title_sort prognostic roles of mrna expression of s100 in non-small-cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828052/
https://www.ncbi.nlm.nih.gov/pubmed/29607329
http://dx.doi.org/10.1155/2018/9815806
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