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Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study

BACKGROUND: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO(3)(−)) and nitrite (NO(2)(−)) and cardiovascular events, we assessed possible effects of dietary NO(3)(−) and NO(2)(−), in the context of total antioxidant capacity (TAC) of the diet, with the...

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Autores principales: Bahadoran, Zahra, Carlström, Mattias, Ghasemi, Asghar, Mirmiran, Parvin, Azizi, Fereidoun, Hadaegh, Farzad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828061/
https://www.ncbi.nlm.nih.gov/pubmed/29492096
http://dx.doi.org/10.1186/s12986-018-0254-2
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author Bahadoran, Zahra
Carlström, Mattias
Ghasemi, Asghar
Mirmiran, Parvin
Azizi, Fereidoun
Hadaegh, Farzad
author_facet Bahadoran, Zahra
Carlström, Mattias
Ghasemi, Asghar
Mirmiran, Parvin
Azizi, Fereidoun
Hadaegh, Farzad
author_sort Bahadoran, Zahra
collection PubMed
description BACKGROUND: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO(3)(−)) and nitrite (NO(2)(−)) and cardiovascular events, we assessed possible effects of dietary NO(3)(−) and NO(2)(−), in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes. METHODS: Adult men and women without CVD (n = 2369) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 6.7 years. Dietary NO(3)(−) and NO(2)(−) intakes, as well as dietary TAC and nitric oxide (NO) index were assessed at baseline (2006–2008). Multivariable-adjusted Cox proportional hazards regression models were used to estimate risk of CVD above and below median of dietary intakes of NO(3)(−)/NO(2)(−) and dietary TAC and NO index. Due to a significant interaction between NO(3)(−)/NO(2)(−) intake and TAC, stratified analyses were done for < and ≥ median dietary TAC. RESULTS: Daily mean (SD) dietary NO(3)(−) and NO(2)(−) intakes were 460 (195) and 9.5 (3.9) mg; mean (SD) dietary TAC and NO index was 1406 (740) and 338 (197) μmol trolox equivalent (TE)/100 g. In subjects with lower dietary TAC, higher intake of NO(3)(−) (≥ 430 mg/d) was accompanied with an increased risk of CVD (HR = 3.28, 95% CI = 1.54–6.99). There were no significant associations between dietary intakes of NO(2)(−), TAC of the diet and NO index with the occurrence of CVD events during the study follow-up. CONCLUSION: High habitual intake of NO(3)(−), in the context of low TAC of the food, may be associated with the risk of CVD outcomes.
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spelling pubmed-58280612018-02-28 Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study Bahadoran, Zahra Carlström, Mattias Ghasemi, Asghar Mirmiran, Parvin Azizi, Fereidoun Hadaegh, Farzad Nutr Metab (Lond) Research BACKGROUND: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO(3)(−)) and nitrite (NO(2)(−)) and cardiovascular events, we assessed possible effects of dietary NO(3)(−) and NO(2)(−), in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes. METHODS: Adult men and women without CVD (n = 2369) were recruited from the Tehran Lipid and Glucose Study and were followed for a mean of 6.7 years. Dietary NO(3)(−) and NO(2)(−) intakes, as well as dietary TAC and nitric oxide (NO) index were assessed at baseline (2006–2008). Multivariable-adjusted Cox proportional hazards regression models were used to estimate risk of CVD above and below median of dietary intakes of NO(3)(−)/NO(2)(−) and dietary TAC and NO index. Due to a significant interaction between NO(3)(−)/NO(2)(−) intake and TAC, stratified analyses were done for < and ≥ median dietary TAC. RESULTS: Daily mean (SD) dietary NO(3)(−) and NO(2)(−) intakes were 460 (195) and 9.5 (3.9) mg; mean (SD) dietary TAC and NO index was 1406 (740) and 338 (197) μmol trolox equivalent (TE)/100 g. In subjects with lower dietary TAC, higher intake of NO(3)(−) (≥ 430 mg/d) was accompanied with an increased risk of CVD (HR = 3.28, 95% CI = 1.54–6.99). There were no significant associations between dietary intakes of NO(2)(−), TAC of the diet and NO index with the occurrence of CVD events during the study follow-up. CONCLUSION: High habitual intake of NO(3)(−), in the context of low TAC of the food, may be associated with the risk of CVD outcomes. BioMed Central 2018-02-27 /pmc/articles/PMC5828061/ /pubmed/29492096 http://dx.doi.org/10.1186/s12986-018-0254-2 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Bahadoran, Zahra
Carlström, Mattias
Ghasemi, Asghar
Mirmiran, Parvin
Azizi, Fereidoun
Hadaegh, Farzad
Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title_full Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title_fullStr Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title_full_unstemmed Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title_short Total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: A longitudinal follow-up in Tehran Lipid and Glucose Study
title_sort total antioxidant capacity of the diet modulates the association between habitual nitrate intake and cardiovascular events: a longitudinal follow-up in tehran lipid and glucose study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828061/
https://www.ncbi.nlm.nih.gov/pubmed/29492096
http://dx.doi.org/10.1186/s12986-018-0254-2
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