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Circulating microRNA-196a is an early gastric cancer biomarker

MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detec...

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Detalles Bibliográficos
Autores principales: Chen, Tsung-Hsing, Lee, Chieh, Chiu, Cheng-Tang, Chu, Yin-Yi, Cheng, Hao-Tsai, Hsu, Jun-Te, Tsou, Yung-Kuan, Wu, Ren-Chin, Chen, Tse-Ching, Chang, Nien-Chen, Yeh, Ta-Sen, Lin, Kwang-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828184/
https://www.ncbi.nlm.nih.gov/pubmed/29535809
http://dx.doi.org/10.18632/oncotarget.23126
Descripción
Sumario:MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls. The area under the receiver operating characteristic curve (AUC) for healthy controls vs. intestinal metaplasia was 0.9736; healthy controls vs. low-grade/high-grade dysplasia 0.9495; and healthy controls vs. early gastric cancer 0.9318. These results indicate that circulating miRNA-196a is a novel biomarker for detection of early gastric cancer and its precursor.