The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target

The mechanisms underlying persistent fibroblast activation and myofibroblast phenoconversion in underlying multi-organ fibrosis in systemic sclerosis (SSc) remain incompletely understood, hindering effective therapies to slow or reverse the process. Cyclin-dependent kinase 5 (CDK5) is a pleiotropic...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Jun, Marangoni, Roberta G., Fang, Feng, Wang, Wenxia, Huang, Jingang, Distler, Joerg H.W., Varga, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828185/
https://www.ncbi.nlm.nih.gov/pubmed/29535807
http://dx.doi.org/10.18632/oncotarget.23516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828185/
https://www.ncbi.nlm.nih.gov/pubmed/29535807
http://dx.doi.org/10.18632/oncotarget.23516

Ejemplares similares