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The non-neuronal cyclin-dependent kinase 5 is a fibrotic mediator potentially implicated in systemic sclerosis and a novel therapeutic target

The mechanisms underlying persistent fibroblast activation and myofibroblast phenoconversion in underlying multi-organ fibrosis in systemic sclerosis (SSc) remain incompletely understood, hindering effective therapies to slow or reverse the process. Cyclin-dependent kinase 5 (CDK5) is a pleiotropic...

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Detalles Bibliográficos
Autores principales:	Wei, Jun, Marangoni, Roberta G., Fang, Feng, Wang, Wenxia, Huang, Jingang, Distler, Joerg H.W., Varga, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828185/ https://www.ncbi.nlm.nih.gov/pubmed/29535807 http://dx.doi.org/10.18632/oncotarget.23516

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