Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage

The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of the chromatin-modifying enzyme EZH2. Work from ot...

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Detalles Bibliográficos
Autores principales: Caruso, Lisa B., Martin, Kayla A., Lauretti, Elisabetta, Hulse, Michael, Siciliano, Micheal, Lupey-Green, Lena N., Abraham, Aaron, Skorski, Tomasz, Tempera, Italo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828221/
https://www.ncbi.nlm.nih.gov/pubmed/29535829
http://dx.doi.org/10.18632/oncotarget.24291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828221/
https://www.ncbi.nlm.nih.gov/pubmed/29535829
http://dx.doi.org/10.18632/oncotarget.24291

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