Cargando…

Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage

The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of the chromatin-modifying enzyme EZH2. Work from ot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caruso, Lisa B., Martin, Kayla A., Lauretti, Elisabetta, Hulse, Michael, Siciliano, Micheal, Lupey-Green, Lena N., Abraham, Aaron, Skorski, Tomasz, Tempera, Italo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828221/ https://www.ncbi.nlm.nih.gov/pubmed/29535829 http://dx.doi.org/10.18632/oncotarget.24291

Ejemplares similares

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1
por: Hulse, Michael, et al.
Publicado: (2018)

PARP1 Stabilizes CTCF Binding and Chromatin Structure To Maintain Epstein-Barr Virus Latency Type
por: Lupey-Green, Lena N., et al.
Publicado: (2018)

PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter
por: Lupey-Green, Lena N., et al.
Publicado: (2017)

Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy
por: Jannetti, Stephen A., et al.
Publicado: (2020)

Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)
por: Zhang, Zhimin, et al.
Publicado: (2020)

The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
por: De Soto, Joseph A., et al.
Publicado: (2006)

Poly(ADP-Ribose) Polymerase 1 (PARP-1) Regulates Ribosomal Biogenesis in Drosophila Nucleoli
por: Boamah, Ernest K., et al.
Publicado: (2012)

EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer
por: Yamaguchi, Hirohito, et al.
Publicado: (2017)

Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression
por: Mattiussi, Stefania, et al.
Publicado: (2007)

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
por: Noël, Georges, et al.
Publicado: (2003)

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes
por: Agarwal, Ashok, et al.
Publicado: (2009)

Clinical Application of Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Prostate Cancer
por: Inderjeeth, Andrisha-Jade, et al.
Publicado: (2022)

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
por: Piskunova, Tatiana S., et al.
Publicado: (2008)

PARP2 Is the Predominant Poly(ADP-Ribose) Polymerase in Arabidopsis DNA Damage and Immune Responses
por: Song, Junqi, et al.
Publicado: (2015)

Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer
por: Wang, Yufeng, et al.
Publicado: (2014)

Doxorubicin-induced necrosis is mediated by poly-(ADP-ribose) polymerase 1 (PARP1) but is independent of p53
por: Shin, Hyeon-Jun, et al.
Publicado: (2015)

Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors
por: Faraoni, Isabella, et al.
Publicado: (2018)

DNA Repair Enzyme Poly(ADP-Ribose) Polymerase 1/2 (PARP1/2)-Targeted Nuclear Imaging and Radiotherapy
por: Nguyen, Nghia T., et al.
Publicado: (2022)

The role of EZH1 and EZH2 in development and cancer
por: Lee, Soo Hyun, et al.
Publicado: (2022)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy
por: Harrision, Daniel, et al.
Publicado: (2020)

BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents
por: Darabi, Sourat, et al.
Publicado: (2022)

Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53
por: Baumann, Cindy, et al.
Publicado: (2006)

Poly(ADP-Ribose) Polymerase 1 (PARP1) Overexpression in Human Breast Cancer Stem Cells and Resistance to Olaparib
por: Gilabert, Marine, et al.
Publicado: (2014)

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease
por: Salech, Felipe, et al.
Publicado: (2020)

Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation
por: Li, Fangfei, et al.
Publicado: (2022)

Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity
por: Fernández-Marcelo, Tamara, et al.
Publicado: (2014)

High frequency of radiological differential responses with poly(ADP-Ribose) polymerase (PARP) inhibitor therapy
por: Perez-Lopez, Raquel, et al.
Publicado: (2017)

Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?
por: Boussios, Stergios, et al.
Publicado: (2020)

Associations with response to Poly(ADP-ribose) Polymerase (PARP) inhibitors in patients with metastatic breast cancer
por: Desnoyers, A., et al.
Publicado: (2022)

Neighborhood matters: Response to EZH2 methyltransferase inhibitors
por: Gharpure, Kshipra M, et al.
Publicado: (2013)

EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain
por: Weng, Han-Rong, et al.
Publicado: (2023)

Effects of poly (ADP-ribose) polymerase-1 (PARP-1) inhibition on sulfur mustard-induced cutaneous injuries in vitro and in vivo
por: Liu, Feng, et al.
Publicado: (2016)

Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b
por: Dash, Sabyasachi, et al.
Publicado: (2017)

Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation
por: Matteini, Francesca, et al.
Publicado: (2020)

Therapeutic Potentials of Poly (ADP‐Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting
por: Wang, Yan, et al.
Publicado: (2021)

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer Therapeutics
por: Richard, Iain A., et al.
Publicado: (2022)

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate
por: Ström, Cecilia E., et al.
Publicado: (2011)

New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage
por: Gu, Zongying, et al.
Publicado: (2019)

The Level of Ets-1 Protein Is Regulated by Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Cancer Cells to Prevent DNA Damage
por: Legrand, Arnaud J., et al.
Publicado: (2013)

The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis
por: García, Samuel, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_clthi21cv4q6fgcf7jg8eqis7t