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Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study

BACKGROUND: Implantable cardioverter‐defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand. M...

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Autores principales: Looi, Khang‐Li, Sidhu, Karishma, Cooper, Lisa, Dawson, Liane, Slipper, Debbie, Gavin, Andrew, Lever, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828273/
https://www.ncbi.nlm.nih.gov/pubmed/29721113
http://dx.doi.org/10.1002/joa3.12027
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author Looi, Khang‐Li
Sidhu, Karishma
Cooper, Lisa
Dawson, Liane
Slipper, Debbie
Gavin, Andrew
Lever, Nigel
author_facet Looi, Khang‐Li
Sidhu, Karishma
Cooper, Lisa
Dawson, Liane
Slipper, Debbie
Gavin, Andrew
Lever, Nigel
author_sort Looi, Khang‐Li
collection PubMed
description BACKGROUND: Implantable cardioverter‐defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand. METHOD: Heart failure patients with systolic dysfunction who underwent primary prevention ICD/cardiac resynchronization therapy‐defibrillator (CRT‐D) implantation between January 1, 2007, and June 1, 2015, were included. Complications, mortality, and hospitalization events were reviewed. RESULTS: Three hundred and eighty‐five primary prevention devices were implanted (269 ICD, 116 CRT‐D). Mean age at implant was 59.1 ± 11.4 years. Mean duration of follow‐up was 3.64 ± 2.17 years. The commonest cause of death was heart failure (41.8%). Only 2 patients died from sudden arrhythmic death. The 5‐year heart failure mortality rate was 6%, whereas the 5‐year sudden arrhythmic death rate was 0.3%. Heart failure hospitalizations were commoner in those who received ICD than CRT‐D (67.7% vs 25.8%, P < .001). Maori patients have low implant rates (14%) with relatively high rates of admissions with heart failure and ventricular arrhythmia admissions, CONCLUSIONS: Even in appropriately selected heart failure patients who received primary prevention devices, only a small percentage died as a result of sudden arrhythmic death. CRT‐D should be the device of choice where appropriate in heart failure patients. Significant challenges remain to improve access to device therapy and maximize benefit to those who do get implanted.
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spelling pubmed-58282732018-05-02 Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study Looi, Khang‐Li Sidhu, Karishma Cooper, Lisa Dawson, Liane Slipper, Debbie Gavin, Andrew Lever, Nigel J Arrhythm Original Articles BACKGROUND: Implantable cardioverter‐defibrillator (ICD) therapy is indicated for selected heart failure patients for the primary prevention of sudden cardiac death. Little is known about the outcomes in patients selected for primary prevention device therapy in the northern region of New Zealand. METHOD: Heart failure patients with systolic dysfunction who underwent primary prevention ICD/cardiac resynchronization therapy‐defibrillator (CRT‐D) implantation between January 1, 2007, and June 1, 2015, were included. Complications, mortality, and hospitalization events were reviewed. RESULTS: Three hundred and eighty‐five primary prevention devices were implanted (269 ICD, 116 CRT‐D). Mean age at implant was 59.1 ± 11.4 years. Mean duration of follow‐up was 3.64 ± 2.17 years. The commonest cause of death was heart failure (41.8%). Only 2 patients died from sudden arrhythmic death. The 5‐year heart failure mortality rate was 6%, whereas the 5‐year sudden arrhythmic death rate was 0.3%. Heart failure hospitalizations were commoner in those who received ICD than CRT‐D (67.7% vs 25.8%, P < .001). Maori patients have low implant rates (14%) with relatively high rates of admissions with heart failure and ventricular arrhythmia admissions, CONCLUSIONS: Even in appropriately selected heart failure patients who received primary prevention devices, only a small percentage died as a result of sudden arrhythmic death. CRT‐D should be the device of choice where appropriate in heart failure patients. Significant challenges remain to improve access to device therapy and maximize benefit to those who do get implanted. John Wiley and Sons Inc. 2017-12-26 /pmc/articles/PMC5828273/ /pubmed/29721113 http://dx.doi.org/10.1002/joa3.12027 Text en © 2017 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Looi, Khang‐Li
Sidhu, Karishma
Cooper, Lisa
Dawson, Liane
Slipper, Debbie
Gavin, Andrew
Lever, Nigel
Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title_full Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title_fullStr Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title_full_unstemmed Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title_short Long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: An observational study
title_sort long‐term outcomes of heart failure patients who received primary prevention implantable cardioverter‐defibrillator: an observational study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828273/
https://www.ncbi.nlm.nih.gov/pubmed/29721113
http://dx.doi.org/10.1002/joa3.12027
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