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Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?

Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases h...

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Autores principales: Oliveira, Cristiano Claudino, Paschoalini, Rafael Bispo, Domingues, Maria Aparecida Custódio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828283/
https://www.ncbi.nlm.nih.gov/pubmed/29515976
http://dx.doi.org/10.4322/acr.2018.001
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author Oliveira, Cristiano Claudino
Paschoalini, Rafael Bispo
Domingues, Maria Aparecida Custódio
author_facet Oliveira, Cristiano Claudino
Paschoalini, Rafael Bispo
Domingues, Maria Aparecida Custódio
author_sort Oliveira, Cristiano Claudino
collection PubMed
description Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection.
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spelling pubmed-58282832018-03-07 Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway? Oliveira, Cristiano Claudino Paschoalini, Rafael Bispo Domingues, Maria Aparecida Custódio Autops Case Rep Letter to the Editor Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects. We evaluated in particular, if apoptosis may be unbalanced in this disease. All cases have morphological and immunohistochemical features consistent with the diagnosis of histiocytic sarcoma. The markers CD163, CD68, vimentin, lysozyme, and S-100 were positive in all cases. Similarly, the three samples were positive for Fas-ligand and Caspase-3. It is well-known that neoplasms may induce increased levels of Fas-ligand with the blockade of the apoptosis process. In the context of HS, the increased Fas-ligand expression represents a new area for research. Indeed, it is linked to proinflammatory stimulus and, maybe with the association of an infection. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2018-02-27 /pmc/articles/PMC5828283/ /pubmed/29515976 http://dx.doi.org/10.4322/acr.2018.001 Text en Autopsy and Case Reports. ISSN 2236-1960. Copyright © 2018. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the article is properly cited.
spellingShingle Letter to the Editor
Oliveira, Cristiano Claudino
Paschoalini, Rafael Bispo
Domingues, Maria Aparecida Custódio
Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title_full Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title_fullStr Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title_full_unstemmed Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title_short Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
title_sort fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828283/
https://www.ncbi.nlm.nih.gov/pubmed/29515976
http://dx.doi.org/10.4322/acr.2018.001
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