Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis

Costello syndrome is a “RASopathy” that is characterized by growth retardation, dysmorphic facial appearance, hypertrophic cardiomyopathy and tumor predisposition. > 80% of patients with Costello syndrome harbor a heterozygous germline G12S mutation in HRAS. Altered metabolic regulation has been...

Descripción completa

Detalles Bibliográficos
Autores principales: Oba, Daiju, Inoue, Shin-ichi, Miyagawa-Tomita, Sachiko, Nakashima, Yasumi, Niihori, Tetsuya, Yamaguchi, Seiji, Matsubara, Yoichi, Aoki, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828294/
https://www.ncbi.nlm.nih.gov/pubmed/29254681
http://dx.doi.org/10.1016/j.ebiom.2017.11.029

Ejemplares similares

Ejemplares similares