LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait. Hamsters, like humans, have the cholesteryl ester transfer protein, intestine-onl...

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Detalles Bibliográficos
Autores principales: Guo, Xin, Gao, Mingming, Wang, Yunan, Lin, Xiao, Yang, Liu, Cong, Nathan, An, Xiangbo, Wang, Feng, Qu, Kai, Yu, Liqing, Wang, Yuhui, Wang, Jinjie, Zhu, Haibo, Xian, Xunde, Liu, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828369/
https://www.ncbi.nlm.nih.gov/pubmed/29289533
http://dx.doi.org/10.1016/j.ebiom.2017.12.013

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