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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss. The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD patients and in drusen deposits. However, it is poorly understood how increased levels of HtrA1 affect the physiological...
Autores principales: | Melo, Esther, Oertle, Philipp, Trepp, Carolyn, Meistermann, Hélène, Burgoyne, Thomas, Sborgi, Lorenzo, Cabrera, Alvaro Cortes, Chen, Chia-yi, Hoflack, Jean-Christophe, Kam-Thong, Tony, Schmucki, Roland, Badi, Laura, Flint, Nicholas, Ghiani, Zeynep Eren, Delobel, Fréderic, Stucki, Corinne, Gromo, Giulia, Einhaus, Alfred, Hornsperger, Benoit, Golling, Sabrina, Siebourg-Polster, Juliane, Gerber, Francoise, Bohrmann, Bernd, Futter, Clare, Dunkley, Tom, Hiller, Sebastian, Schilling, Oliver, Enzmann, Volker, Fauser, Sascha, Plodinec, Marija, Iacone, Roberto |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828370/ https://www.ncbi.nlm.nih.gov/pubmed/29269042 http://dx.doi.org/10.1016/j.ebiom.2017.12.011 |
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