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Competent for commitment: you've got to have heart!

The mature heart is composed primarily of four different cell types: cardiac myocytes, endothelium, smooth muscle, and fibroblasts. These cell types derive from pluripotent progenitors that become progressively restricted with regard to lineage potential, giving rise to multipotent cardiac progenito...

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Detalles Bibliográficos
Autores principales: Jain, Rajan, Epstein, Jonathan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828393/
https://www.ncbi.nlm.nih.gov/pubmed/29440224
http://dx.doi.org/10.1101/gad.308353.117
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author Jain, Rajan
Epstein, Jonathan A.
author_facet Jain, Rajan
Epstein, Jonathan A.
author_sort Jain, Rajan
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description The mature heart is composed primarily of four different cell types: cardiac myocytes, endothelium, smooth muscle, and fibroblasts. These cell types derive from pluripotent progenitors that become progressively restricted with regard to lineage potential, giving rise to multipotent cardiac progenitor cells and, ultimately, the differentiated cell types of the heart. Recent studies have begun to shed light on the defining characteristics of the intermediary cell types that exist transiently during this developmental process and the extrinsic and cell-autonomous factors that influence cardiac lineage decisions and cellular competence. This information will shape our understanding of congenital and adult cardiac disease and guide regenerative therapeutic approaches. In addition, cardiac progenitor specification can serve as a model for understanding basic mechanisms regulating the acquisition of cellular identity. In this review, we present the concept of “chromatin competence” that describes the potential for three-dimensional chromatin organization to function as the molecular underpinning of the ability of a progenitor cell to respond to inductive lineage cues and summarize recent studies advancing our understanding of cardiac cell specification, gene regulation, and chromatin organization and how they impact cardiac development.
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spelling pubmed-58283932018-07-01 Competent for commitment: you've got to have heart! Jain, Rajan Epstein, Jonathan A. Genes Dev Review The mature heart is composed primarily of four different cell types: cardiac myocytes, endothelium, smooth muscle, and fibroblasts. These cell types derive from pluripotent progenitors that become progressively restricted with regard to lineage potential, giving rise to multipotent cardiac progenitor cells and, ultimately, the differentiated cell types of the heart. Recent studies have begun to shed light on the defining characteristics of the intermediary cell types that exist transiently during this developmental process and the extrinsic and cell-autonomous factors that influence cardiac lineage decisions and cellular competence. This information will shape our understanding of congenital and adult cardiac disease and guide regenerative therapeutic approaches. In addition, cardiac progenitor specification can serve as a model for understanding basic mechanisms regulating the acquisition of cellular identity. In this review, we present the concept of “chromatin competence” that describes the potential for three-dimensional chromatin organization to function as the molecular underpinning of the ability of a progenitor cell to respond to inductive lineage cues and summarize recent studies advancing our understanding of cardiac cell specification, gene regulation, and chromatin organization and how they impact cardiac development. Cold Spring Harbor Laboratory Press 2018-01-01 /pmc/articles/PMC5828393/ /pubmed/29440224 http://dx.doi.org/10.1101/gad.308353.117 Text en © 2018 Jain and Epstein; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Jain, Rajan
Epstein, Jonathan A.
Competent for commitment: you've got to have heart!
title Competent for commitment: you've got to have heart!
title_full Competent for commitment: you've got to have heart!
title_fullStr Competent for commitment: you've got to have heart!
title_full_unstemmed Competent for commitment: you've got to have heart!
title_short Competent for commitment: you've got to have heart!
title_sort competent for commitment: you've got to have heart!
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828393/
https://www.ncbi.nlm.nih.gov/pubmed/29440224
http://dx.doi.org/10.1101/gad.308353.117
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