Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16(INK4a) inactivation

BACKGROUND: The preferential use of aerobic glycolysis by tumor cells lead to high accumulation of lactate in tumor microenvironment. Clinical evidence has linked elevated lactate concentration with cancer outcomes. However, the role and molecular mechanisms of lactate in cellular senescence and tum...

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Detalles Bibliográficos
Autores principales: Li, Xiangrui, Zhang, Zhijian, Zhang, Yao, Cao, Yuxiang, Wei, Huijun, Wu, Zhihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828408/
https://www.ncbi.nlm.nih.gov/pubmed/29482580
http://dx.doi.org/10.1186/s13046-018-0701-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828408/
https://www.ncbi.nlm.nih.gov/pubmed/29482580
http://dx.doi.org/10.1186/s13046-018-0701-y

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