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Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease
Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828413/ https://www.ncbi.nlm.nih.gov/pubmed/29607312 http://dx.doi.org/10.1155/2018/9025841 |
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author | Lu, Heng Chen, Yi Li, Linlin |
author_facet | Lu, Heng Chen, Yi Li, Linlin |
author_sort | Lu, Heng |
collection | PubMed |
description | Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients' serum. |
format | Online Article Text |
id | pubmed-5828413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58284132018-04-01 Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease Lu, Heng Chen, Yi Li, Linlin Int J Genomics Research Article Coronary artery disease (CAD) is one of the leading threats to global health. Previous research has proven that metabolic pathway disorders, such as high blood lipids and diabetes, are one of the risk factors that mostly cause CAD. However, the crosstalk between metabolic pathways and CAD was mostly studied on physiology processes by analyzing a single gene function. A canonical correlation analysis was used to identify the metabolic pathways, which were integrated as a unit to coexpress with CAD susceptibility genes, and to resolve additional metabolic factors that are related to CAD. Seven pathways, including citrate cycle, ubiquinone, terpenoid quinone biosynthesis, and N-glycan biosynthesis, were identified as an integrated unit coexpressed with CAD genes. These pathways could not be revealed as a coexpressed pathway through traditional methods as each single gene has weak correlation. Furthermore, sets of genes in these pathways were candidate markers for diagnosis and detection from patients' serum. Hindawi 2018-02-11 /pmc/articles/PMC5828413/ /pubmed/29607312 http://dx.doi.org/10.1155/2018/9025841 Text en Copyright © 2018 Heng Lu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lu, Heng Chen, Yi Li, Linlin Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title_full | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title_fullStr | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title_full_unstemmed | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title_short | Metabolic Pathway Genes Associated with Susceptibility Genes to Coronary Artery Disease |
title_sort | metabolic pathway genes associated with susceptibility genes to coronary artery disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828413/ https://www.ncbi.nlm.nih.gov/pubmed/29607312 http://dx.doi.org/10.1155/2018/9025841 |
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