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Correcting for 16S rRNA gene copy numbers in microbiome surveys remains an unsolved problem

The 16S ribosomal RNA gene is the most widely used marker gene in microbial ecology. Counts of 16S sequence variants, often in PCR amplicons, are used to estimate proportions of bacterial and archaeal taxa in microbial communities. Because different organisms contain different 16S gene copy numbers...

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Detalles Bibliográficos
Autores principales: Louca, Stilianos, Doebeli, Michael, Parfrey, Laura Wegener
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828423/
https://www.ncbi.nlm.nih.gov/pubmed/29482646
http://dx.doi.org/10.1186/s40168-018-0420-9