Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications

In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells....

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Autores principales: Guo, Xiaofei, Bai, Yan, Zhang, Li, Zhang, Bo, Zagidullin, Naufal, Carvalho, Katherine, Du, Zhimin, Cai, Benzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828435/
https://www.ncbi.nlm.nih.gov/pubmed/29482607
http://dx.doi.org/10.1186/s13287-018-0773-9
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author Guo, Xiaofei
Bai, Yan
Zhang, Li
Zhang, Bo
Zagidullin, Naufal
Carvalho, Katherine
Du, Zhimin
Cai, Benzhi
author_facet Guo, Xiaofei
Bai, Yan
Zhang, Li
Zhang, Bo
Zagidullin, Naufal
Carvalho, Katherine
Du, Zhimin
Cai, Benzhi
author_sort Guo, Xiaofei
collection PubMed
description In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells. Current research indicates that chemical substances, microRNAs, and cytokines have biological functions that regulate the cardiomyocytes differentiation of BMSCs. In this review, we chiefly summarize the regulatory factors that induce BMSCs to differentiate into cardiomyocytes.
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spelling pubmed-58284352018-03-01 Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications Guo, Xiaofei Bai, Yan Zhang, Li Zhang, Bo Zagidullin, Naufal Carvalho, Katherine Du, Zhimin Cai, Benzhi Stem Cell Res Ther Review In the past years, cardiac mortality has decreased, but cardiac diseases are still responsible for millions of deaths every year worldwide. Bone-marrow mesenchymal stem cells (BMSCs) transplantation may be a promising therapeutic strategy because of its capacity to differentiate into cardiac cells. Current research indicates that chemical substances, microRNAs, and cytokines have biological functions that regulate the cardiomyocytes differentiation of BMSCs. In this review, we chiefly summarize the regulatory factors that induce BMSCs to differentiate into cardiomyocytes. BioMed Central 2018-02-26 /pmc/articles/PMC5828435/ /pubmed/29482607 http://dx.doi.org/10.1186/s13287-018-0773-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Guo, Xiaofei
Bai, Yan
Zhang, Li
Zhang, Bo
Zagidullin, Naufal
Carvalho, Katherine
Du, Zhimin
Cai, Benzhi
Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title_full Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title_fullStr Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title_full_unstemmed Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title_short Cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
title_sort cardiomyocyte differentiation of mesenchymal stem cells from bone marrow: new regulators and its implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828435/
https://www.ncbi.nlm.nih.gov/pubmed/29482607
http://dx.doi.org/10.1186/s13287-018-0773-9
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