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Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals
Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828484/ https://www.ncbi.nlm.nih.gov/pubmed/29482568 http://dx.doi.org/10.1186/s12958-018-0334-1 |
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author | Cao, Xiaodan Cui, Yun Zhang, Xiaoxia Lou, Jiangtao Zhou, Jun Bei, Huafeng Wei, Renxiong |
author_facet | Cao, Xiaodan Cui, Yun Zhang, Xiaoxia Lou, Jiangtao Zhou, Jun Bei, Huafeng Wei, Renxiong |
author_sort | Cao, Xiaodan |
collection | PubMed |
description | Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance. |
format | Online Article Text |
id | pubmed-5828484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58284842018-03-01 Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals Cao, Xiaodan Cui, Yun Zhang, Xiaoxia Lou, Jiangtao Zhou, Jun Bei, Huafeng Wei, Renxiong Reprod Biol Endocrinol Review Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance. BioMed Central 2018-02-27 /pmc/articles/PMC5828484/ /pubmed/29482568 http://dx.doi.org/10.1186/s12958-018-0334-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Cao, Xiaodan Cui, Yun Zhang, Xiaoxia Lou, Jiangtao Zhou, Jun Bei, Huafeng Wei, Renxiong Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title_full | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title_fullStr | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title_full_unstemmed | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title_short | Proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
title_sort | proteomic profile of human spermatozoa in healthy and asthenozoospermic individuals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828484/ https://www.ncbi.nlm.nih.gov/pubmed/29482568 http://dx.doi.org/10.1186/s12958-018-0334-1 |
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