Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients

BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients. METHODS: Clozapine...

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Detalles Bibliográficos
Autores principales: Menkes, David B., Glue, Paul, Gale, Christopher, Lam, Frederic, Hung, Cheung-Tak, Hung, Noelyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828556/
https://www.ncbi.nlm.nih.gov/pubmed/29254680
http://dx.doi.org/10.1016/j.ebiom.2017.11.030

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