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Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM

Histidine biosynthesis is an essential process in plants and microorganisms, making it an attractive target for the development of herbicides and antibacterial agents. Imidazoleglycerol-phosphate dehydratase (IGPD), a key enzyme within this pathway, has been biochemically characterized in both Sacch...

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Detalles Bibliográficos
Autores principales:	Rawson, Shaun, Bisson, Claudine, Hurdiss, Daniel L., Fazal, Asif, McPhillie, Martin J., Sedelnikova, Svetlana E., Baker, Patrick J., Rice, David W., Muench, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828572/ https://www.ncbi.nlm.nih.gov/pubmed/29434040 http://dx.doi.org/10.1073/pnas.1708839115

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