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Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neutralizing antibodies (bnAbs) have been reported to...

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Detalles Bibliográficos
Autores principales:	Ovchinnikov, Victor, Louveau, Joy E, Barton, John P, Karplus, Martin, Chakraborty, Arup K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828663/ https://www.ncbi.nlm.nih.gov/pubmed/29442996 http://dx.doi.org/10.7554/eLife.33038

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