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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

To provide insight into pharmacological treatment of hyperuricemia we developed a semi‐mechanistic, dynamical model of uric acid (UA) disposition in human. Our model represents the hyperuricemic state in terms of production of UA (rate, PUA), its renal filtration (glomerular filtration rate, GFR) an...

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Detalles Bibliográficos
Autores principales:	Aksenov, Sergey, Peck, Carl C., Eriksson, Ulf G., Stanski, Donald R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828935/ https://www.ncbi.nlm.nih.gov/pubmed/29488355 http://dx.doi.org/10.14814/phy2.13614

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